Source:http://linkedlifedata.com/resource/pubmed/id/12925885
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2003-8-19
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AC007550,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AC127480,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY123427,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY123428,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY123429
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pubmed:abstractText |
We analyzed 137 kb covering human neurofibromatosis 2 ( NF2) tumor suppressor locus and orthologous loci from baboon, mouse, rat, and pufferfish Takifugu rubripes. A predominant feature of human-rodent conservation is a very similar distribution of conserved islands, regarding length, position, and degree of identity. By use of a threshold of 75% identity over > or =100 bp of gap-free alignment, comparisons of human-mouse sequences resulted in 3.58% for extra-exonic conservation, which can be compared to 4.5% of exonic sequence content within the human locus. We identified a duplication of neurofibromin 2 in pufferfish, which resulted in two putative proteins with 74% and 76% identity to the human protein. One distinct island (called inter 1), conserved between all analyzed species, was located between promoters of the NIPSNAP1 and NF2 genes. Inter 1 might represent a novel regulatory element, important for the function of this locus. The high level of intronic conservation in the NF2 locus suggests that a number of unknown regulatory elements might exist within this gene. These elements could be affected by disease-causing mutations in NF2 patients and NF2-associated tumors. Alternatively, this conservation might be explained by presence of not yet characterized transcriptional unit(s) within this locus.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0938-8990
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
526-36
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12925885-Amino Acid Sequence,
pubmed-meshheading:12925885-Animals,
pubmed-meshheading:12925885-Cluster Analysis,
pubmed-meshheading:12925885-Conserved Sequence,
pubmed-meshheading:12925885-Gene Duplication,
pubmed-meshheading:12925885-Gene Library,
pubmed-meshheading:12925885-Genes, Neurofibromatosis 2,
pubmed-meshheading:12925885-Humans,
pubmed-meshheading:12925885-Mammals,
pubmed-meshheading:12925885-Models, Genetic,
pubmed-meshheading:12925885-Molecular Sequence Data,
pubmed-meshheading:12925885-Phylogeny,
pubmed-meshheading:12925885-Proteins,
pubmed-meshheading:12925885-Sequence Alignment,
pubmed-meshheading:12925885-Sequence Homology,
pubmed-meshheading:12925885-Takifugu
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pubmed:year |
2003
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pubmed:articleTitle |
Strong conservation of the human NF2 locus based on sequence comparison in five species.
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pubmed:affiliation |
Department of Genetics and Pathology, Rudbeck Laboratory, 3rd floor, Dag Hammarskjöds väg 20, Uppsala University, 751 85 Uppsala, Sweden.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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