Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-8-19
pubmed:abstractText
Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have both been implicated in the last step of Ii degradation that gives rise to the class II-associated invariant chain peptides (CLIP). Cat V has been recently described as highly homologous to Cat L and exclusively expressed in human thymus and testis, but with no mouse orthologue. We report that Cat V is the dominant cysteine protease in cortical human thymic epithelial cells, while Cat L and Cat S seem to be restricted to dendritic and macrophage-like cells. Active Cat V in thymic lysosomal preparations was demonstrated by active-site labeling. Recombinant Cat V was capable of converting Ii into CLIP efficiently, suggesting that Cat V is the protease that controls the generation of alphabeta-CLIP complexes in the human thymus, in analogy to Cat L in mouse. Comparison of Cat V expression between thymi from patients with myasthenia gravis and healthy controls revealed a significantly higher expression level in the pathological samples, suggesting a potential involvement of this protease in the immunopathogenesis of myasthenia gravis, an autoimmune disease almost invariably associated with thymic pathology.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-10029531, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-10072073, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-10382972, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-10469135, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-10485263, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-10574149, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-10679409, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-10748235, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-11048948, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-11160348, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-11169395, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-11445126, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-11456312, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-11465117, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-12070022, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-12748383, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-1373173, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-2449461, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-3874554, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-6608726, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-7044372, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-7600288, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-7606781, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-7836909, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-8011283, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-8612130, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-8655355, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-8845771, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-8920889, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-9130635, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-9145318, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-9545226, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-9563472, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-9601080, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-9616206, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-9645368, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-9872320, http://linkedlifedata.com/resource/pubmed/commentcorrection/12925692-9950753
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation..., http://linkedlifedata.com/resource/pubmed/chemical/CTSL1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CTSL2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin L, http://linkedlifedata.com/resource/pubmed/chemical/Cathepsins, http://linkedlifedata.com/resource/pubmed/chemical/Ctsl protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/cathepsin S, http://linkedlifedata.com/resource/pubmed/chemical/invariant chain
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
517-26
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
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