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pubmed-article:12925275pubmed:abstractTextFebrile (fever-induced) seizures are the most common form of childhood seizures, affecting 3%-5% of infants and young children. Here we show that the activity-dependent, retrograde inhibition of GABA release by endogenous cannabinoids is persistently enhanced in the rat hippocampus following a single episode of experimental prolonged febrile seizures during early postnatal development. The potentiation of endocannabinoid signaling results from an increase in the number of presynaptic cannabinoid type 1 receptors associated with cholecystokinin-containing perisomatic inhibitory inputs, without an effect on the endocannabinoid-mediated inhibition of glutamate release. These results demonstrate a selective, long-term increase in the gain of endocannabinoid-mediated retrograde signaling at GABAergic synapses in a model of a human neurological disease.lld:pubmed
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pubmed-article:12925275pubmed:articleTitleLong-term plasticity of endocannabinoid signaling induced by developmental febrile seizures.lld:pubmed
pubmed-article:12925275pubmed:affiliationDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.lld:pubmed
pubmed-article:12925275pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12925275pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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