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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-8-19
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pubmed:abstractText |
Febrile (fever-induced) seizures are the most common form of childhood seizures, affecting 3%-5% of infants and young children. Here we show that the activity-dependent, retrograde inhibition of GABA release by endogenous cannabinoids is persistently enhanced in the rat hippocampus following a single episode of experimental prolonged febrile seizures during early postnatal development. The potentiation of endocannabinoid signaling results from an increase in the number of presynaptic cannabinoid type 1 receptors associated with cholecystokinin-containing perisomatic inhibitory inputs, without an effect on the endocannabinoid-mediated inhibition of glutamate release. These results demonstrate a selective, long-term increase in the gain of endocannabinoid-mediated retrograde signaling at GABAergic synapses in a model of a human neurological disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
599-611
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12925275-Action Potentials,
pubmed-meshheading:12925275-Animals,
pubmed-meshheading:12925275-Blotting, Western,
pubmed-meshheading:12925275-Cells, Cultured,
pubmed-meshheading:12925275-Chromatography, High Pressure Liquid,
pubmed-meshheading:12925275-Disease Models, Animal,
pubmed-meshheading:12925275-Electric Stimulation,
pubmed-meshheading:12925275-Endocannabinoids,
pubmed-meshheading:12925275-Excitatory Amino Acid Antagonists,
pubmed-meshheading:12925275-Fatty Acids, Unsaturated,
pubmed-meshheading:12925275-Hippocampus,
pubmed-meshheading:12925275-Hyperthermia, Induced,
pubmed-meshheading:12925275-Immunohistochemistry,
pubmed-meshheading:12925275-Long-Term Potentiation,
pubmed-meshheading:12925275-Mass Spectrometry,
pubmed-meshheading:12925275-Microscopy, Electron,
pubmed-meshheading:12925275-Neuronal Plasticity,
pubmed-meshheading:12925275-Neurons,
pubmed-meshheading:12925275-Patch-Clamp Techniques,
pubmed-meshheading:12925275-Presynaptic Terminals,
pubmed-meshheading:12925275-Rats,
pubmed-meshheading:12925275-Rats, Sprague-Dawley,
pubmed-meshheading:12925275-Receptors, Cannabinoid,
pubmed-meshheading:12925275-Receptors, Drug,
pubmed-meshheading:12925275-Seizures, Febrile,
pubmed-meshheading:12925275-Synaptic Transmission,
pubmed-meshheading:12925275-gamma-Aminobutyric Acid
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pubmed:year |
2003
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pubmed:articleTitle |
Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures.
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pubmed:affiliation |
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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