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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2003-8-19
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pubmed:abstractText |
The CagA protein of Helicobacter pylori is directly injected from the bacteria into cells via the bacterial type IV secretion system and undergoes tyrosine phosphorylation in the gastric epithelial cells. Translocated CagA forms a physical complex with the SRC homology 2 domain (SH2)-containing tyrosine phosphatase SHP-2, which plays an important role in mitogenic signal transduction in the host cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/PTPN11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Trl protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0269-2813
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-44
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12925139-Bacterial Proteins,
pubmed-meshheading:12925139-DNA-Binding Proteins,
pubmed-meshheading:12925139-Drosophila Proteins,
pubmed-meshheading:12925139-Epithelial Cells,
pubmed-meshheading:12925139-Female,
pubmed-meshheading:12925139-Gastric Mucosa,
pubmed-meshheading:12925139-Helicobacter Infections,
pubmed-meshheading:12925139-Helicobacter pylori,
pubmed-meshheading:12925139-Homeodomain Proteins,
pubmed-meshheading:12925139-Humans,
pubmed-meshheading:12925139-Immunoblotting,
pubmed-meshheading:12925139-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12925139-Male,
pubmed-meshheading:12925139-Middle Aged,
pubmed-meshheading:12925139-Phosphorylation,
pubmed-meshheading:12925139-Polymerase Chain Reaction,
pubmed-meshheading:12925139-Precipitin Tests,
pubmed-meshheading:12925139-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:12925139-Protein Tyrosine Phosphatases,
pubmed-meshheading:12925139-Signal Transduction,
pubmed-meshheading:12925139-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells.
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pubmed:affiliation |
Second Department of Internal Medicine, Fukui Medical University, Fukui 910-1193, Japan. azuma@fmsrsa.fukui-med.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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