Source:http://linkedlifedata.com/resource/pubmed/id/12924717
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-8-19
|
| pubmed:abstractText |
The authors report on two gonadotropic carcinomas of the adenohypophysis that occurred in a55-year-old man (Case 1) and a 53-year-old woman (Case 2), with signs of mass effect and amenorrhea, respectively. Both lesions were macroadenomas. The tumor in Case 1 metastasized to dura mater, skull, nasal sinus, and larynx 2 years after patient presentation, whereas that in Case 2 spread to vertebral bodies and ribs after a 19-year latency. Histologically, the primary, recurrent, and metastatic lesions in Case 1 featured brisk mitotic activity and high MIB-1 levels as well as p53 labeling indices. Immunoreactivity for HER-2/neu was assessable only in rare neoplastic cells of the second recurrence and in 80% of cells of the dural metastasis. Low-level HER-2/neu gene amplification was evident in the recurrent tumors and metastasis. The sellar and metastatic tumors in Case 2 resembled benign gonadotropic adenoma with oncocytic change; p53 accumulation, HER-2/neu overexpression, and HER-2/neu gene amplification were not present. The results indicate that low-level amplification of the HER-2/neu gene might be associated with pituitary carcinomas in which more aggressive behavior is seen. Further studies are needed to determine whether HER-2/neu plays a role in the pathogenesis of pituitary carcinoma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-3085
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| pubmed:author |
pubmed-author:BishopMari CMC,
pubmed-author:FletcherJonathan AJA,
pubmed-author:HorvathEvaE,
pubmed-author:HsiBradleyB,
pubmed-author:KovacsKalmanK,
pubmed-author:LloydRicardo VRV,
pubmed-author:NoséVaniaV,
pubmed-author:RoncaroliFedericoF,
pubmed-author:ScheithauerBernd WBW,
pubmed-author:YoungWilliam FWFJr
|
| pubmed:issnType |
Print
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
402-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:12924717-Brain Neoplasms,
pubmed-meshheading:12924717-Carcinoma,
pubmed-meshheading:12924717-Dura Mater,
pubmed-meshheading:12924717-Female,
pubmed-meshheading:12924717-Gene Amplification,
pubmed-meshheading:12924717-Genes, erbB-2,
pubmed-meshheading:12924717-Gonadotropins,
pubmed-meshheading:12924717-Humans,
pubmed-meshheading:12924717-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12924717-Laryngeal Neoplasms,
pubmed-meshheading:12924717-Magnetic Resonance Imaging,
pubmed-meshheading:12924717-Male,
pubmed-meshheading:12924717-Middle Aged,
pubmed-meshheading:12924717-Neoplasms,
pubmed-meshheading:12924717-Paranasal Sinus Neoplasms,
pubmed-meshheading:12924717-Pituitary Neoplasms,
pubmed-meshheading:12924717-Skull Neoplasms,
pubmed-meshheading:12924717-Tomography, X-Ray Computed
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Gonadotropic pituitary carcinoma: HER-2/neu expression and gene amplification. Report of two cases.
|
| pubmed:affiliation |
Department of Oncology, Bellaria Hospital, Bologna, Italy.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|