|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
25-26
|
|
pubmed:dateCreated |
2003-8-18
|
|
pubmed:abstractText |
We evaluated antibody responses and protection induced by attenuated Wa human rotavirus (AttHRV) and VP2/6-rotavirus-like particles (VLP), 100 or 250 microg/dose, with immunostimulating complexes (ISCOM) (VLP/ISCOM) each given orally, alone or sequentially to gnotobiotic pigs. The AttHRV-VLP 250 microg/ISCOM and three-dose-AttHRV (AttHRV3x) groups had significantly higher serum IgA, IgG and intestinal IgA antibody titers to HRV pre-challenge than the three-dose-VLP 100 microg/ISCOM group (VLP/ISCOM3x) and controls (diluent/ISCOMmatrix). Protection rates against viral shedding and diarrhea were highest in the AttHRV-VLP250 microg/ISCOM and AttHRV3x groups, lower in the AttHRV-VLP 100 microg/ISCOM group, with no protection in the VLP/ISCOM3x group and controls. Thus, VLP/ISCOM boosted antibody titers and protection after priming with AttHRV.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Rotavirus Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Attenuated
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0264-410X
|
|
pubmed:author |
pubmed-author:AzevedoM S PMS,
pubmed-author:ChangK-OKO,
pubmed-author:IosefCC,
pubmed-author:JeongKK,
pubmed-author:KimYY,
pubmed-author:LewisPP,
pubmed-author:Lovgren-BengtssonKK,
pubmed-author:MoreinBB,
pubmed-author:NguyenT VTV,
pubmed-author:NielsenPP,
pubmed-author:SaifL JLJ,
pubmed-author:YuanLL
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4059-70
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12922143-Adjuvants, Immunologic,
pubmed-meshheading:12922143-Animals,
pubmed-meshheading:12922143-Antibodies, Monoclonal,
pubmed-meshheading:12922143-Antibodies, Viral,
pubmed-meshheading:12922143-Diarrhea,
pubmed-meshheading:12922143-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12922143-Germ-Free Life,
pubmed-meshheading:12922143-Humans,
pubmed-meshheading:12922143-Immunization, Secondary,
pubmed-meshheading:12922143-Immunoglobulin A,
pubmed-meshheading:12922143-Immunoglobulin G,
pubmed-meshheading:12922143-Mice,
pubmed-meshheading:12922143-Neutralization Tests,
pubmed-meshheading:12922143-Rotavirus,
pubmed-meshheading:12922143-Rotavirus Infections,
pubmed-meshheading:12922143-Rotavirus Vaccines,
pubmed-meshheading:12922143-Swine,
pubmed-meshheading:12922143-Vaccines, Attenuated,
pubmed-meshheading:12922143-Viral Plaque Assay,
pubmed-meshheading:12922143-Virus Shedding
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Protection and antibody responses to oral priming by attenuated human rotavirus followed by oral boosting with 2/6-rotavirus-like particles with immunostimulating complexes in gnotobiotic pigs.
|
|
pubmed:affiliation |
Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691-4096, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
