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pubmed:abstractText |
Determining the existence of syndrome-specific genetic factors in epilepsy is essential for phenotype definition in genetic linkage studies, and informs research on basic mechanisms. Analysis of concordance of epilepsy syndromes in families has been used to assess shared versus distinct genetic influences on generalized epilepsy (GE) and localization-related epilepsy (LRE). However, it is unclear how the results should be interpreted in relation to specific genetic hypotheses.
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pubmed:affiliation |
G. H. Sergievsky Center, and Departments of Neurology Statistics Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA.
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