Linked Life Data

12919132

Source:http://linkedlifedata.com/resource/pubmed/id/12919132

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pubmed-article:12919132pubmed:abstractTextA functional polymorphism (the upstream variable-number tandem repeat region, or uVNTR) in the monoamine oxidase A (MAOA) promoter region has been reported to be associated with behavioral abnormalities as well as increased serotonergic responsivity. We examined the relation between MAOA-uVNTR alleles and the phenotypic expression of autism in 41 males younger than 12.6 years of age. Children with the low-activity MAOA allele had both lower intelligence quotients (IQ) and more severe autistic behavior than children with the high-activity allele. In follow-up testing of 34 of the males at the 1-year time-point, those with the low-activity allele showed a worsening in IQ but no change in the severity of their autistic behavior. We conclude that functional MAOA-uVNTR alleles may act as a genetic modifier of the severity of autism in males.lld:pubmed
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pubmed-article:12919132pubmed:articleTitleAssociation of autism severity with a monoamine oxidase A functional polymorphism.lld:pubmed
pubmed-article:12919132pubmed:affiliationDepartments of Psychology, Cytogenetics and Human Genetics, Staten Island, New York 10314, USA. Ira.Cohen@omr.state.ny.uslld:pubmed
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