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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-8-15
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pubmed:abstractText |
A functional polymorphism (the upstream variable-number tandem repeat region, or uVNTR) in the monoamine oxidase A (MAOA) promoter region has been reported to be associated with behavioral abnormalities as well as increased serotonergic responsivity. We examined the relation between MAOA-uVNTR alleles and the phenotypic expression of autism in 41 males younger than 12.6 years of age. Children with the low-activity MAOA allele had both lower intelligence quotients (IQ) and more severe autistic behavior than children with the high-activity allele. In follow-up testing of 34 of the males at the 1-year time-point, those with the low-activity allele showed a worsening in IQ but no change in the severity of their autistic behavior. We conclude that functional MAOA-uVNTR alleles may act as a genetic modifier of the severity of autism in males.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0009-9163
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
190-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12919132-Activities of Daily Living,
pubmed-meshheading:12919132-Adaptation, Psychological,
pubmed-meshheading:12919132-Alleles,
pubmed-meshheading:12919132-Autistic Disorder,
pubmed-meshheading:12919132-Child,
pubmed-meshheading:12919132-Child, Preschool,
pubmed-meshheading:12919132-Cognition,
pubmed-meshheading:12919132-Female,
pubmed-meshheading:12919132-Follow-Up Studies,
pubmed-meshheading:12919132-Genetics, Behavioral,
pubmed-meshheading:12919132-Genotype,
pubmed-meshheading:12919132-Humans,
pubmed-meshheading:12919132-Intelligence Tests,
pubmed-meshheading:12919132-Language Tests,
pubmed-meshheading:12919132-Longitudinal Studies,
pubmed-meshheading:12919132-Male,
pubmed-meshheading:12919132-Minisatellite Repeats,
pubmed-meshheading:12919132-Monoamine Oxidase,
pubmed-meshheading:12919132-Promoter Regions, Genetic,
pubmed-meshheading:12919132-Psychological Tests,
pubmed-meshheading:12919132-Severity of Illness Index,
pubmed-meshheading:12919132-Sex Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Association of autism severity with a monoamine oxidase A functional polymorphism.
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pubmed:affiliation |
Departments of Psychology, Cytogenetics and Human Genetics, Staten Island, New York 10314, USA. Ira.Cohen@omr.state.ny.us
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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