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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
17
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pubmed:dateCreated |
2003-8-15
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pubmed:abstractText |
The total synthesis of the potent microtubule-stabilizing, antimitotic agent (+)-discodermolide is described. The convergent synthetic strategy takes advantage of the diastereoselective alkylation of a ketone enolate to establish the key C15-C16 bond. The synthesis is amenable to preparation of gram-scale quantities of (+)-discodermolide and analogues.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-3263
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
22
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|
pubmed:volume |
68
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
6646-60
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12919029-Alkanes,
pubmed-meshheading:12919029-Alkylation,
pubmed-meshheading:12919029-Antineoplastic Agents,
pubmed-meshheading:12919029-Carbamates,
pubmed-meshheading:12919029-Indicators and Reagents,
pubmed-meshheading:12919029-Lactones,
pubmed-meshheading:12919029-Microtubules,
pubmed-meshheading:12919029-Models, Molecular,
pubmed-meshheading:12919029-Molecular Conformation,
pubmed-meshheading:12919029-Pyrones
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide.
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|
pubmed:affiliation |
Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, USA.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
