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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2003-8-13
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pubmed:abstractText |
Despite its clinical success, methotrexate (MTX) therapy is associated with toxicities such as seizures, the pathogenesis of which remains unclear. It has been suggested that hyperhomocysteinemia is caused by MTX and is responsible for its neurotoxic effects. The purposes of this study were to explore whether hyperhomocysteinemia was related to MTX administration and toxicity and whether homocysteine or MTX toxicity differed by methylenetetrahydrofolate reductase (MTHFR) or reduced folate carrier (RFC) genetic polymorphisms.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:CookEdwin HEH,
pubmed-author:DasSomaS,
pubmed-author:GrienerJamesJ,
pubmed-author:HudsonMelissaM,
pubmed-author:KishiShinjiS,
pubmed-author:PeiDeqingD,
pubmed-author:PuiChing-HonCH,
pubmed-author:RellingMary VMV,
pubmed-author:RubnitzJeffreyJ,
pubmed-author:SandlundJohn TJT,
pubmed-author:XXX
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3084-91
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12915598-Carrier Proteins,
pubmed-meshheading:12915598-Child,
pubmed-meshheading:12915598-Homocysteine,
pubmed-meshheading:12915598-Humans,
pubmed-meshheading:12915598-Hyperhomocysteinemia,
pubmed-meshheading:12915598-Membrane Transport Proteins,
pubmed-meshheading:12915598-Methotrexate,
pubmed-meshheading:12915598-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:12915598-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:12915598-Polymorphism, Genetic,
pubmed-meshheading:12915598-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:12915598-Reduced Folate Carrier Protein
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pubmed:year |
2003
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pubmed:articleTitle |
Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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