Source:http://linkedlifedata.com/resource/pubmed/id/12915450
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
|
| pubmed:dateCreated |
2003-9-16
|
| pubmed:abstractText |
The apolipoprotein A5 gene (APOA5 ) has been shown to play an important role in determining plasma triglyceride concentrations in humans. We describe here a novel variant, c.553G>T, in the apolipoprotein A5 gene that is associated with hypertriglyceridemia. In contrast to some other polymorphisms, which occur in non-coding regions of the gene, this variant occurs within the coding region and causes the change of amino acid sequence (a substitution of a cysteine for a glycine residue). The minor allele frequencies were 0.042 and 0.27 (P<0.001) for control and hypertriglyceridemic patients, respectively. The serum triglyceride level was significantly different among the genotypic groups (G/G 92.5+/-37.8 mg/dl, G/T 106.6+/-34.8 mg/dl, T/T 183.0 mg/dl, P=0.014) in control subjects. Multiple logistic regression revealed individuals carrying the minor allele had age, gender and BMI (body mass index)-adjusted odds ratio of 11.73 (95% confidence interval of 6.617-20.793; P<0.0001) for developing hypertriglyceridemia in comparison to individuals without that allele. These findings suggest the possible use of c.553G>T polymorphisms in APOA5 as prognostic indicators for hypertriglyceridemia susceptibility in Chinese.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins A,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0964-6906
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2533-9
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:12915450-Age Factors,
pubmed-meshheading:12915450-Amino Acid Substitution,
pubmed-meshheading:12915450-Apolipoproteins A,
pubmed-meshheading:12915450-Asian Continental Ancestry Group,
pubmed-meshheading:12915450-Body Mass Index,
pubmed-meshheading:12915450-Cholesterol,
pubmed-meshheading:12915450-Cholesterol, HDL,
pubmed-meshheading:12915450-Cholesterol, LDL,
pubmed-meshheading:12915450-Female,
pubmed-meshheading:12915450-Gene Frequency,
pubmed-meshheading:12915450-Genetic Predisposition to Disease,
pubmed-meshheading:12915450-Genetic Variation,
pubmed-meshheading:12915450-Glycine,
pubmed-meshheading:12915450-Haplotypes,
pubmed-meshheading:12915450-Humans,
pubmed-meshheading:12915450-Hypertriglyceridemia,
pubmed-meshheading:12915450-Linkage Disequilibrium,
pubmed-meshheading:12915450-Logistic Models,
pubmed-meshheading:12915450-Male,
pubmed-meshheading:12915450-Odds Ratio,
pubmed-meshheading:12915450-Polymorphism, Genetic,
pubmed-meshheading:12915450-Sex Ratio
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia.
|
| pubmed:affiliation |
School and Graduate Institute of Medical Technology, College of Medicine, and Department of Laboratory Medicine, University Hospital, National Taiwan University, No. 7, Chung-Shan S. Rd, Taipei, 100 Taiwan. jtkao@ha.mc.ntu.edu.tw
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|