Source:http://linkedlifedata.com/resource/pubmed/id/12915382
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2003-11-5
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| pubmed:abstractText |
Tubulointerstitial fibrosis is a hallmark feature of chronic renal injury. Specific therapies to control the progression of renal fibrosis toward end-stage renal failure are limited. Previous studies have demonstrated that expression of endogenous bone morphogenic protein-7 (BMP-7) is reduced in the kidneys of several inducible mouse models of acute and chronic renal disease and that administration of exogenous recombinant human BMP-7 (rhBMP-7) has a beneficial effect on kidney function. Here we report that treatment with rhBMP-7 leads to improved renal function, histology, and survival in mice deficient in the alpha3-chain of type IV collagen and MRL/MpJlpr/lpr lupus mice, two genetic models for chronic renal injury and fibrosis. Such therapeutic benefit is also associated with a significant decrease in the expression of profibrotic molecules, such as type I collagen and fibronectin, in renal fibroblasts. Additionally, rhBMP-7 induces expression of active matrix metalloproteinase-2, which is potentially important for removal of fibrotic matrix. Collectively, these studies provide further evidence for rhBMP-7 as an important bone-associated protein with protective function against renal pathology.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/BMP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 7,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type IV,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/type IV collagen alpha3 chain
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1931-857X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
285
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
F1060-7
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| pubmed:dateRevised |
2011-4-28
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| pubmed:meshHeading |
pubmed-meshheading:12915382-Animals,
pubmed-meshheading:12915382-Autoantigens,
pubmed-meshheading:12915382-Bone Morphogenetic Protein 7,
pubmed-meshheading:12915382-Bone Morphogenetic Proteins,
pubmed-meshheading:12915382-Cells, Cultured,
pubmed-meshheading:12915382-Collagen Type IV,
pubmed-meshheading:12915382-Disease Models, Animal,
pubmed-meshheading:12915382-Female,
pubmed-meshheading:12915382-Fibroblasts,
pubmed-meshheading:12915382-Fibrosis,
pubmed-meshheading:12915382-Humans,
pubmed-meshheading:12915382-Kidney Failure, Chronic,
pubmed-meshheading:12915382-Lupus Nephritis,
pubmed-meshheading:12915382-Mice,
pubmed-meshheading:12915382-Mice, Inbred MRL lpr,
pubmed-meshheading:12915382-Mice, Mutant Strains,
pubmed-meshheading:12915382-Neuroprotective Agents,
pubmed-meshheading:12915382-Transforming Growth Factor beta
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| pubmed:year |
2003
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| pubmed:articleTitle |
Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models.
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| pubmed:affiliation |
Center for Matrix Biology, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|