Linked Life Data

12915220

Source:http://linkedlifedata.com/resource/pubmed/id/12915220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2003-8-13
pubmed:abstractText
The effect of apolipoprotein E genotype and polymorphisms of lipoprotein lipase gene on plasma postprandial triglyceride levels in familial combined hyperlipidemic subjects and their relatives have not been sufficiently studied. This study included sixteen familial combined hyperlipidemic parents (G1): age: 52 +/- 9 years with total-cholesterol: 7.2 +/- 1.7 mmol/L, fasting triglycerides: 2.8 +/- 1.4 mmol/L and sixteen children (G2) (twelve were normolipidemic): of age: 22 +/- 5 years with total-cholesterol: 5.2 +/- 1.1 mmol/L, fasting triglycerides: 2.06 +/- 1.8 mmol/L and twelve normolipidemic, healthy controls. Blood samples were taken fasting and 2, 4, 6, 8, 10 hr postprandially after the standard fat rich test meal. We determined lipid parameters, apolipoprotein E and lipoprotein lipase HindIII and PvuII polymorphisms as well. The 6-hr critical postprandial triglyceride values were abnormal in both G1: 5.88 +/- 2.7 mmol/L and G2: 3.53 +/- 2.7 mmol/L (p <0.001), respectively, and differed significantly (p <0.001) from each other. The subjects of familial combined hyperlipidemic families with E4 allele in both generations exhibited significantly (p <0.001) higher and extended postprandial lipemia. We did not find significant effects of lipoprotein lipase HindIII or PvuII polymorphisms on the fasting lipid values alone, however in normolipidemic subjects from the same families the homozygosity of HindIII variation was associated with higher triglyceride postprandial peak (p <0.01). The main findings of our study are that i.) normolipidemic G2 subjects in familial combined hyperlipidemic families have already abnormal postprandial status, and ii.) the 6 h postprandial triglyceride values were correlated with fasting triglyceride levels, which showed association with the apolipoprotein E4 allele.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0955-2863
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
394-400
pubmed:dateRevised
2008-8-19
pubmed:meshHeading
pubmed-meshheading:12915220-Adolescent, pubmed-meshheading:12915220-Adult, pubmed-meshheading:12915220-Apolipoprotein E4, pubmed-meshheading:12915220-Apolipoproteins E, pubmed-meshheading:12915220-Child, pubmed-meshheading:12915220-Cholesterol, pubmed-meshheading:12915220-DNA, pubmed-meshheading:12915220-Deoxyribonuclease HindIII, pubmed-meshheading:12915220-Deoxyribonucleases, Type II Site-Specific, pubmed-meshheading:12915220-Fasting, pubmed-meshheading:12915220-Food, pubmed-meshheading:12915220-Genotype, pubmed-meshheading:12915220-Homozygote, pubmed-meshheading:12915220-Humans, pubmed-meshheading:12915220-Hyperlipidemia, Familial Combined, pubmed-meshheading:12915220-Lipoprotein Lipase, pubmed-meshheading:12915220-Middle Aged, pubmed-meshheading:12915220-Polymorphism, Restriction Fragment Length, pubmed-meshheading:12915220-Triglycerides
pubmed:year
2003
pubmed:articleTitle
Postprandial triglyceride levels in familial combined hyperlipidemia. The role of apolipoprotein E and lipoprotein lipase polymorphisms.
pubmed:affiliation
Department of Internal Medicine, Szent György Hospital Székesfehérvár, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary.
pubmed:publicationType
Journal Article