Source:http://linkedlifedata.com/resource/pubmed/id/12915207
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2003-8-13
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pubmed:abstractText |
Adenosine (Ado), a naturally occurring autacoid, exerts cardioprotective effects against myocardial ischemia and reperfusion injury, through activation of its receptors type 1 (A1) and 2A (A2A). Since ageing involves a complex change in these effects, we evaluated A1 and A2A gene expression in left (LV) and right ventricle (RV) from 2-, 5-, 12-, and 21-month-old Sprague-Dawley rats. LV end-diastolic (EDD) and end-systolic (ESD) internal dimensions (mm) and LV fractional shortening (FS, %) were measured by M-mode echocardiography. Senescence was associated with a reduction in FS (42+/-1, 38+/-2, 39+/-2 and 35+/-2, in 2-, 5-, 12- and 21-month-old rats; p<0.02) and increases in EDD (7.5+/-0.2, 8.1+/-0.2, 8.5+/-0.2 and 8.8+/-0.2; p<0.001) and ESD (4.2+/-0.1, 4.4+/-0.2, 4.7+/-0.2 and 5.1+/-0.2; p=0.002). Ado A1 mRNA levels were highest in 12 and 21-month-old animals in both ventricles (LV: p<0.001; RV: p=0.001). By contrast, Ado A2A gene expression was lower in the aged LV (p<0.001), but higher in the aged RV (p<0.001). These modifications of Ado receptor gene expression and especially the increase in A1 receptor mRNA may partially explain the stronger antiadrenergic effects of Ado in the senescent heart.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0531-5565
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
855-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12915207-Aging,
pubmed-meshheading:12915207-Animals,
pubmed-meshheading:12915207-Echocardiography,
pubmed-meshheading:12915207-Gene Expression,
pubmed-meshheading:12915207-Heart Ventricles,
pubmed-meshheading:12915207-Male,
pubmed-meshheading:12915207-Myocardium,
pubmed-meshheading:12915207-RNA, Messenger,
pubmed-meshheading:12915207-Rats,
pubmed-meshheading:12915207-Rats, Sprague-Dawley,
pubmed-meshheading:12915207-Receptor, Adenosine A1,
pubmed-meshheading:12915207-Receptor, Adenosine A2A,
pubmed-meshheading:12915207-Receptor Cross-Talk,
pubmed-meshheading:12915207-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2003
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pubmed:articleTitle |
Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium.
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pubmed:affiliation |
Department of Internal Medicine and Gerontology, Ospedale Maggiore IRCCS, Cattedra di Geron. e Geriatria, Via Pace 9, 20122 Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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