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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-8-13
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pubmed:abstractText |
Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-Il6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-34
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12914697-CCAAT-Enhancer-Binding Protein-beta,
pubmed-meshheading:12914697-Cyclin D1,
pubmed-meshheading:12914697-Databases, Genetic,
pubmed-meshheading:12914697-Gene Expression Profiling,
pubmed-meshheading:12914697-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12914697-Humans,
pubmed-meshheading:12914697-Neoplasm Proteins,
pubmed-meshheading:12914697-Neoplasms,
pubmed-meshheading:12914697-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:12914697-Promoter Regions, Genetic,
pubmed-meshheading:12914697-Statistics, Nonparametric,
pubmed-meshheading:12914697-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.
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pubmed:affiliation |
Departments of Medical Oncology and Medicine, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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