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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-8-12
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pubmed:abstractText |
Pancreatic resection for pancreatic cancer is the only curative modality, but the high incidence of local recurrence after surgery results in a very poor prognosis. This study aims to develop a new therapeutic tool that could inhibit the growth of remnant cancer cells, which is based on local delivery of NK4 (hepatocyte growth factor antagonist) secreted from an NK4 gene-transduced oral mucosal epithelial cell (OMEC) sheet (NK4-sheet), which is adhered to the resected surface. Experimental design: OMECs, harvested and cultured according to 3T3 feeder layer technique, were seeded on a collagen mesh-overlayered, biodegradable VICRYL mesh to produce an OMEC sheet. NK4 gene transduction was mediated by recombinant adenovirus (Ad-NK4). Applicability of OMECs for cell-based NK4 delivery was examined. An experimental model using nude mice was established to determine the effect of an NK4-sheet on both tumor growth and angiogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3158-66
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12912968-Adenoviridae,
pubmed-meshheading:12912968-Animals,
pubmed-meshheading:12912968-Biocompatible Materials,
pubmed-meshheading:12912968-Cell Adhesion,
pubmed-meshheading:12912968-Cell Division,
pubmed-meshheading:12912968-Cell Line, Tumor,
pubmed-meshheading:12912968-Collagen,
pubmed-meshheading:12912968-Epithelial Cells,
pubmed-meshheading:12912968-Female,
pubmed-meshheading:12912968-Gene Transfer Techniques,
pubmed-meshheading:12912968-Hepatocyte Growth Factor,
pubmed-meshheading:12912968-Humans,
pubmed-meshheading:12912968-Mice,
pubmed-meshheading:12912968-Mice, Nude,
pubmed-meshheading:12912968-Mitogens,
pubmed-meshheading:12912968-Models, Biological,
pubmed-meshheading:12912968-Mouth Mucosa,
pubmed-meshheading:12912968-Neoplasm Invasiveness,
pubmed-meshheading:12912968-Neoplasm Transplantation,
pubmed-meshheading:12912968-Neovascularization, Pathologic,
pubmed-meshheading:12912968-Pancreatic Neoplasms,
pubmed-meshheading:12912968-Polyglactin 910,
pubmed-meshheading:12912968-Prognosis,
pubmed-meshheading:12912968-Rats,
pubmed-meshheading:12912968-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12912968-Time Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Cell-based protein delivery system for the inhibition of the growth of pancreatic cancer: NK4 gene-transduced oral mucosal epithelial cell sheet.
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pubmed:affiliation |
Divisions of Biomedical Engineering and Surgery and Oncology, Graduate School of Medicine, Kyushu University, Maidashi, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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