|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2003-8-12
|
|
pubmed:abstractText |
Malignant mesothelioma is a uniformly fatal cancer of the pleural and peritoneal spaces. Several challenging clinical problems include poor understanding of the pathophysiology, inaccurate diagnosis from tissue samples, and unsuccessful treatment strategies. The purpose of this study was to use microarray analysis to identify specific gene expression changes in mesothelioma compared with normal mesothelium. Experimental Design: We performed gene expression analysis on mesothelioma tissue specimens from 16 patients and compared these to 4 control pleural tissue samples using cDNA microarray filters with 4132 clones. Multiple normalization and analysis approaches were used. Quantitative reverse transcription-PCR and immunohistochemistry were used to validate results.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anions,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Galectin 3,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Vault Ribonucleoprotein Particles,
http://linkedlifedata.com/resource/pubmed/chemical/adenotin,
http://linkedlifedata.com/resource/pubmed/chemical/major vault protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
pubmed-author:AlbeldaSteven MSM,
pubmed-author:AminKunjlata MKM,
pubmed-author:FriedbergJosephJ,
pubmed-author:JohnsonSteven WSW,
pubmed-author:KaiserLarry RLR,
pubmed-author:KucharczukJohn CJC,
pubmed-author:LitzkyLeslie ALA,
pubmed-author:MaldenLiliana DLD,
pubmed-author:MatzieKimberlyK,
pubmed-author:SinghalSunilS,
pubmed-author:WiewrodtRainerR
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3080-97
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:12912960-Aged,
pubmed-meshheading:12912960-Anions,
pubmed-meshheading:12912960-Carrier Proteins,
pubmed-meshheading:12912960-Cytoskeleton,
pubmed-meshheading:12912960-DNA, Complementary,
pubmed-meshheading:12912960-Down-Regulation,
pubmed-meshheading:12912960-Female,
pubmed-meshheading:12912960-Galectin 3,
pubmed-meshheading:12912960-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12912960-Glucose,
pubmed-meshheading:12912960-Humans,
pubmed-meshheading:12912960-Immunohistochemistry,
pubmed-meshheading:12912960-Lung Neoplasms,
pubmed-meshheading:12912960-Male,
pubmed-meshheading:12912960-Mesothelioma,
pubmed-meshheading:12912960-Middle Aged,
pubmed-meshheading:12912960-Models, Biological,
pubmed-meshheading:12912960-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:12912960-Peroxidases,
pubmed-meshheading:12912960-RNA,
pubmed-meshheading:12912960-RNA, Messenger,
pubmed-meshheading:12912960-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12912960-Tumor Markers, Biological,
pubmed-meshheading:12912960-Up-Regulation,
pubmed-meshheading:12912960-Vault Ribonucleoprotein Particles
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Gene expression profiling of malignant mesothelioma.
|
|
pubmed:affiliation |
Section of Thoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
