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rdf:type |
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lifeskim:mentions |
umls-concept:C0005456,
umls-concept:C0017337,
umls-concept:C0033706,
umls-concept:C0086222,
umls-concept:C0086418,
umls-concept:C0205245,
umls-concept:C1149367,
umls-concept:C1335858,
umls-concept:C1415627,
umls-concept:C1415629,
umls-concept:C1442756,
umls-concept:C1705733,
umls-concept:C1880022
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pubmed:issue |
8
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pubmed:dateCreated |
2003-8-12
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pubmed:abstractText |
Prothrombin is a key component in blood coagulation. Overexpression of prothrombin leads to an increased risk of venous thrombosis. Therefore, the study of the transcriptional regulation of the prothrombin gene may help to identify mechanisms of overexpression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix Leucine...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FOXA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HNF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HNF1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 3-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/MLX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Prothrombin,
http://linkedlifedata.com/resource/pubmed/chemical/SP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sp1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sp3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1538-7933
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1688-98
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12911579-Animals,
pubmed-meshheading:12911579-Base Sequence,
pubmed-meshheading:12911579-Basic Helix-Loop-Helix Leucine Zipper Transcription Factors,
pubmed-meshheading:12911579-Binding Sites,
pubmed-meshheading:12911579-Cell Line,
pubmed-meshheading:12911579-DNA-Binding Proteins,
pubmed-meshheading:12911579-Databases as Topic,
pubmed-meshheading:12911579-Enhancer Elements, Genetic,
pubmed-meshheading:12911579-Gene Deletion,
pubmed-meshheading:12911579-HeLa Cells,
pubmed-meshheading:12911579-Hepatocyte Nuclear Factor 1,
pubmed-meshheading:12911579-Hepatocyte Nuclear Factor 1-alpha,
pubmed-meshheading:12911579-Hepatocyte Nuclear Factor 1-beta,
pubmed-meshheading:12911579-Hepatocyte Nuclear Factor 3-beta,
pubmed-meshheading:12911579-Hepatocyte Nuclear Factor 4,
pubmed-meshheading:12911579-Humans,
pubmed-meshheading:12911579-Luciferases,
pubmed-meshheading:12911579-Molecular Sequence Data,
pubmed-meshheading:12911579-Mutagenesis, Site-Directed,
pubmed-meshheading:12911579-Mutation,
pubmed-meshheading:12911579-Nuclear Proteins,
pubmed-meshheading:12911579-Phosphoproteins,
pubmed-meshheading:12911579-Phylogeny,
pubmed-meshheading:12911579-Promoter Regions, Genetic,
pubmed-meshheading:12911579-Protein Binding,
pubmed-meshheading:12911579-Prothrombin,
pubmed-meshheading:12911579-Risk,
pubmed-meshheading:12911579-Sequence Homology, Nucleic Acid,
pubmed-meshheading:12911579-Sp1 Transcription Factor,
pubmed-meshheading:12911579-Sp3 Transcription Factor,
pubmed-meshheading:12911579-Transcription, Genetic,
pubmed-meshheading:12911579-Transcription Factors,
pubmed-meshheading:12911579-Transfection,
pubmed-meshheading:12911579-Venous Thrombosis
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pubmed:year |
2003
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pubmed:articleTitle |
Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer.
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pubmed:affiliation |
Department of Haematology, Leiden University Medical Center, Leiden, the Netherlands. hceelie@lumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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