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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-9-1
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pubmed:abstractText |
Although bone marrow is known as a primary lymphoid organ, its potential to serve as a secondary immune organ has hardly been explored. Here we demonstrate that naive, antigen-specific T cells home to bone marrow, where they can be primed. Antigen presentation to T cells in bone marrow is mediated via resident CD11c+ dendritic cells. They are highly efficient in taking up exogenous blood-borne antigen and processing it via major histocompatibility complex class I and class II pathways. T-cell activation correlates with dendritic cell-T cell clustering in bone marrow stroma. Primary CD4+ and CD8+ T-cell responses generated in bone marrow occur in the absence of secondary lymphoid organs. The responses are not tolerogenic and result in generation of cytotoxic T cells, protective anti-tumor immunity and immunological memory. These findings highlight the uniqueness of bone marrow as an organ important for hemato- and lymphopoiesis and for systemic T cell-mediated immunity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11c,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:BeckhovePhilippP,
pubmed-author:FeuererMarkusM,
pubmed-author:GarbiNatalioN,
pubmed-author:HämmerlingGünter JGJ,
pubmed-author:HamannAlfA,
pubmed-author:HommelMirjaM,
pubmed-author:KyewskiBrunoB,
pubmed-author:LimmerAndreasA,
pubmed-author:MahnkeYolandaY,
pubmed-author:SchirrmacherVolkerV,
pubmed-author:UmanskyViktorV
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1151-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12910264-Animals,
pubmed-meshheading:12910264-Antigens,
pubmed-meshheading:12910264-Antigens, CD,
pubmed-meshheading:12910264-Antigens, CD11c,
pubmed-meshheading:12910264-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:12910264-Bone Marrow,
pubmed-meshheading:12910264-Bone Marrow Cells,
pubmed-meshheading:12910264-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12910264-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12910264-Dendritic Cells,
pubmed-meshheading:12910264-Female,
pubmed-meshheading:12910264-Immunologic Memory,
pubmed-meshheading:12910264-Lectins, C-Type,
pubmed-meshheading:12910264-Major Histocompatibility Complex,
pubmed-meshheading:12910264-Mice,
pubmed-meshheading:12910264-Mice, Inbred Strains,
pubmed-meshheading:12910264-Mice, Mutant Strains,
pubmed-meshheading:12910264-Mice, Transgenic,
pubmed-meshheading:12910264-Receptors, Antigen, T-Cell,
pubmed-meshheading:12910264-Splenectomy,
pubmed-meshheading:12910264-T-Lymphocytes
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pubmed:year |
2003
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pubmed:articleTitle |
Bone marrow as a priming site for T-cell responses to blood-borne antigen.
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pubmed:affiliation |
Tumor Immunology Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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