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rdf:type |
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lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0004083,
umls-concept:C0005938,
umls-concept:C0017337,
umls-concept:C0033684,
umls-concept:C0042333,
umls-concept:C0043210,
umls-concept:C0205251,
umls-concept:C0392752,
umls-concept:C0679058,
umls-concept:C1335621,
umls-concept:C1424333,
umls-concept:C1514562,
umls-concept:C1521487,
umls-concept:C1547699,
umls-concept:C1556094,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2700640
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pubmed:issue |
7
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pubmed:dateCreated |
2003-8-11
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pubmed:abstractText |
Twin and family studies had shown that genetic factors are important determinants of bone mass. Multiple genes might be involved. One candidate gene, the reversion-induced LIM gene ( RIL), is a PDZ and LIM-domain-containing protein and has been localized within the cytokine cluster of chromosome 5 (5q31.1). In a genetic study of 370 adult Japanese women, we investigated the correlation between radial bone mineral density (BMD) and a genetic variation (-3333T-->C) of the 5'-flanking region of RIL gene. A significant association was identified between the RIL variation -3333T-->C and radial BMD ( r=0.15, P=0.003). The variation of the RIL locus may be an important determinant of osteoporosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1434-5161
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pubmed:author |
pubmed-author:EmiMitsuruM,
pubmed-author:EzuraYoichiY,
pubmed-author:HosoiTakayukiT,
pubmed-author:InoueSatoshiS,
pubmed-author:IshidaRyotaR,
pubmed-author:KajitaMitsukoM,
pubmed-author:KodairaMinaM,
pubmed-author:OmasuFumihiroF,
pubmed-author:OrimoHajimeH,
pubmed-author:ShirakiMasatakaM,
pubmed-author:SuzukiTakaoT,
pubmed-author:YoshidaHideoH
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
342-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12908099-Adult,
pubmed-meshheading:12908099-Aged,
pubmed-meshheading:12908099-Bone Density,
pubmed-meshheading:12908099-China,
pubmed-meshheading:12908099-Chromosomes, Human, Pair 5,
pubmed-meshheading:12908099-DNA-Binding Proteins,
pubmed-meshheading:12908099-Female,
pubmed-meshheading:12908099-Genetic Predisposition to Disease,
pubmed-meshheading:12908099-Genetic Variation,
pubmed-meshheading:12908099-Genotype,
pubmed-meshheading:12908099-Humans,
pubmed-meshheading:12908099-Japan,
pubmed-meshheading:12908099-LIM Domain Proteins,
pubmed-meshheading:12908099-Middle Aged,
pubmed-meshheading:12908099-Osteoporosis,
pubmed-meshheading:12908099-Polymorphism, Single Nucleotide,
pubmed-meshheading:12908099-Protein Structure, Tertiary
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pubmed:year |
2003
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pubmed:articleTitle |
Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women.
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pubmed:affiliation |
Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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