Source:http://linkedlifedata.com/resource/pubmed/id/12907442
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2003-11-4
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| pubmed:abstractText |
Posttransplantation lymphoproliferative disorders (PTLDs) represent a serious complication of solid organ transplantation. This study assessed the molecular histogenesis of 52 B-cell monoclonal PTLDs, including 12 polymorphic PTLDs (P-PTLDs), 36 diffuse large B-cell lymphomas (DLBCLs), and 4 Burkitt/Burkitt-like lymphomas (BL/BLLs). Somatic hypermutation (SHM) of immunoglobulin variable (IgV) genes documented that most monoclonal B-cell PTLDs (75% P-PTLDs, 91.3% DLBCLs, 100% BL/BLLs) derive from germinal center (GC)-experienced B cells. B-cell lymphoma 6 (BCL6) mutations occurred in 25% P-PTLDs, 60.6% DLBCLs, and 75.0% BL/BLLs. A first histogenetic category of PTLDs (31.2% DLBCLs) express the BCL6+/multiple myeloma oncogene-1 protein (MUM1-/+)/CD138- profile and mimic B cells experiencing the GC reaction, as also suggested by ongoing SHM in a fraction of these cases. A second subset of PTLDs (66.7% P-PTLDs and 31.2% DLBCLs) display the BCL6-/MUM1+/CD138- phenotype and mimic B cells that have concluded the GC reaction. A third histogenetic category of PTLDs (25.0% P-PTLDs and 31.2% DLBCLs) shows the BCL6-/MUM1+/CD138+ profile, consistent with preterminally differentiated post-GC B cells. Crippling mutations of IgV heavy chain (IgVH) and/or IgV light chain (IgVL) genes, leading to sterile rearrangements and normally preventing cell survival, occur in 4 DLBCLs and 1 BL/BLL that may have been rescued from apoptosis through expression of Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1). Overall, the histogenetic diversity of monoclonal B-cell PTLDs may help define biologically homogeneous categories of the disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
|
| pubmed:issn |
0006-4971
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| pubmed:author |
pubmed-author:BerraEvaE,
pubmed-author:CapelloDanielaD,
pubmed-author:CarboneAntoninoA,
pubmed-author:CerriMichaelaM,
pubmed-author:ConconiAnnaritaA,
pubmed-author:DeambrogiClaraC,
pubmed-author:DottiGiampietroG,
pubmed-author:GaidanoGianlucaG,
pubmed-author:GloghiniAnnunziataA,
pubmed-author:IppolitiGiovanbattistaG,
pubmed-author:MagriniUmbertoU,
pubmed-author:MorraEnricaE,
pubmed-author:MutiGiulianaG,
pubmed-author:OrestePierluigiP,
pubmed-author:PaulliMarcoM,
pubmed-author:RambaldiAlessandroA,
pubmed-author:RossiDavideD,
pubmed-author:ViganòMarioM
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
102
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3775-85
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12907442-Adolescent,
pubmed-meshheading:12907442-Adult,
pubmed-meshheading:12907442-Aged,
pubmed-meshheading:12907442-B-Lymphocytes,
pubmed-meshheading:12907442-Base Sequence,
pubmed-meshheading:12907442-Child,
pubmed-meshheading:12907442-Child, Preschool,
pubmed-meshheading:12907442-Female,
pubmed-meshheading:12907442-Gene Rearrangement,
pubmed-meshheading:12907442-Genes, Immunoglobulin,
pubmed-meshheading:12907442-Herpesvirus 4, Human,
pubmed-meshheading:12907442-Humans,
pubmed-meshheading:12907442-Immunophenotyping,
pubmed-meshheading:12907442-Infant,
pubmed-meshheading:12907442-Lymphoproliferative Disorders,
pubmed-meshheading:12907442-Male,
pubmed-meshheading:12907442-Middle Aged,
pubmed-meshheading:12907442-Molecular Sequence Data,
pubmed-meshheading:12907442-Organ Transplantation,
pubmed-meshheading:12907442-Retrospective Studies,
pubmed-meshheading:12907442-Somatic Hypermutation, Immunoglobulin,
pubmed-meshheading:12907442-Viral Matrix Proteins
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Molecular histogenesis of posttransplantation lymphoproliferative disorders.
|
| pubmed:affiliation |
Hematology Unit, Department of Medical Sciences & Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|