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rdf:type |
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lifeskim:mentions |
umls-concept:C0033684,
umls-concept:C0037083,
umls-concept:C0041341,
umls-concept:C0061928,
umls-concept:C0291147,
umls-concept:C0663937,
umls-concept:C0682002,
umls-concept:C1180347,
umls-concept:C1704222,
umls-concept:C1710082,
umls-concept:C2587213
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pubmed:issue |
15
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pubmed:dateCreated |
2003-8-8
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pubmed:abstractText |
Tuberous Sclerosis Complex (TSC) is a genetic disorder that occurs through the loss of heterozygosity of either TSC1 or TSC2, which encode Hamartin or Tuberin, respectively. Tuberin and Hamartin form a tumor suppressor heterodimer that inhibits the mammalian target of rapamycin (mTOR) nutrient signaling input, but how this occurs is unclear.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EIF4EBP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ELF4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Monomeric GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RHEB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/tuberous sclerosis complex 1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/tuberous sclerosis complex 2 protein
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1259-68
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12906785-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12906785-Biological Assay,
pubmed-meshheading:12906785-Blotting, Western,
pubmed-meshheading:12906785-Carrier Proteins,
pubmed-meshheading:12906785-DNA-Binding Proteins,
pubmed-meshheading:12906785-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:12906785-GTPase-Activating Proteins,
pubmed-meshheading:12906785-Humans,
pubmed-meshheading:12906785-Monomeric GTP-Binding Proteins,
pubmed-meshheading:12906785-Mutagenesis, Site-Directed,
pubmed-meshheading:12906785-Neuropeptides,
pubmed-meshheading:12906785-Phosphoproteins,
pubmed-meshheading:12906785-Plasmids,
pubmed-meshheading:12906785-Precipitin Tests,
pubmed-meshheading:12906785-Protein Kinases,
pubmed-meshheading:12906785-Proteins,
pubmed-meshheading:12906785-Repressor Proteins,
pubmed-meshheading:12906785-Ribosomal Protein S6 Kinases,
pubmed-meshheading:12906785-Signal Transduction,
pubmed-meshheading:12906785-TOR Serine-Threonine Kinases,
pubmed-meshheading:12906785-Transcription Factors,
pubmed-meshheading:12906785-Transfection,
pubmed-meshheading:12906785-Tuberous Sclerosis,
pubmed-meshheading:12906785-Tumor Suppressor Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
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pubmed:affiliation |
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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