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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2003-8-7
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pubmed:abstractText |
A recent uroselective alpha(1)-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor alpha(1)-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned alpha(1a)-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their alpha(1A)-antagonist and their NO-donor properties.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADRA1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Adra1a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrous Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Oxadiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Rec 15-2739,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/furoxans
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3762-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12904082-Adrenergic alpha-Antagonists,
pubmed-meshheading:12904082-Animals,
pubmed-meshheading:12904082-Binding, Competitive,
pubmed-meshheading:12904082-CHO Cells,
pubmed-meshheading:12904082-Cerebral Cortex,
pubmed-meshheading:12904082-Chromones,
pubmed-meshheading:12904082-Cricetinae,
pubmed-meshheading:12904082-HeLa Cells,
pubmed-meshheading:12904082-Humans,
pubmed-meshheading:12904082-Male,
pubmed-meshheading:12904082-Muscle, Smooth,
pubmed-meshheading:12904082-Muscle Relaxation,
pubmed-meshheading:12904082-Nitric Oxide Donors,
pubmed-meshheading:12904082-Nitrous Acid,
pubmed-meshheading:12904082-Oxadiazoles,
pubmed-meshheading:12904082-Radioligand Assay,
pubmed-meshheading:12904082-Rats,
pubmed-meshheading:12904082-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:12904082-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:12904082-Receptors, Serotonin,
pubmed-meshheading:12904082-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:12904082-Vas Deferens
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pubmed:year |
2003
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pubmed:articleTitle |
New potential uroselective NO-donor alpha1-antagonists.
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pubmed:affiliation |
Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, via Pietro Giuria 9, 10125 Turin, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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