| pubmed-article:12902197 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12902197 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12902197 | lifeskim:mentions | umls-concept:C1704628 | lld:lifeskim |
| pubmed-article:12902197 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12902197 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12902197 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12902197 | pubmed:dateCreated | 2003-8-6 | lld:pubmed |
| pubmed-article:12902197 | pubmed:abstractText | 4-Methylthioamphetamine (4-MTA), also known as p-methylthioamphetamine, is a new amphetamine derivative which in humans has been increasingly associated with severe intoxications and several deaths. As hyperthermia is considered to be one of the most life-threatening acute physiological consequences of amphetamine-related intoxications, it was our aim to determine whether 4-MTA induces changes in body temperature in a mouse model. Accordingly, we measured the subcutaneous temperature after acute administration of 4-MTA in CD1 mice. Because hyperthermia seems to result from the central and peripheral actions of catecholamines and serotonin (5-hydroxytriptamine or 5-HT), we also investigated the possible interactions of some catecholaminergic and serotonergic receptor blockers and the inhibition of monoamine oxidase (MAO) with this effect. 4-MTA induced hyperthermia in CD1 mice. Blockade of the 5-HT receptors with methysergide and MAO inhibition with pargyline resulted in the potentiation of the 4-MTA-induced hyperthermic effect. Blockade of the alpha(1)-adrenergic receptors with prazosin completely reverted the 4-MTA-induced hyperthermia while with the beta-adrenergic receptor blocker dl-propranolol this reversal was not complete. Blockade of the alpha(2)-adrenergic receptors with yohimbine had no effect on the hyperthermia induced by 4-MTA. These results suggest that 4-MTA-induced hyperthermia is highly influenced by the catecholaminergic and serotonergic receptor activation and the MAO activity. | lld:pubmed |
| pubmed-article:12902197 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12902197 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12902197 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12902197 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12902197 | pubmed:issn | 0041-008X | lld:pubmed |
| pubmed-article:12902197 | pubmed:author | pubmed-author:de BoerDouweD | lld:pubmed |
| pubmed-article:12902197 | pubmed:author | pubmed-author:CarvalhoFélix... | lld:pubmed |
| pubmed-article:12902197 | pubmed:author | pubmed-author:RemiãoFernand... | lld:pubmed |
| pubmed-article:12902197 | pubmed:author | pubmed-author:de Lourdes... | lld:pubmed |
| pubmed-article:12902197 | pubmed:author | pubmed-author:CarmoHelenaH | lld:pubmed |
| pubmed-article:12902197 | pubmed:author | pubmed-author:dos... | lld:pubmed |
| pubmed-article:12902197 | pubmed:author | pubmed-author:FernandesEdua... | lld:pubmed |
| pubmed-article:12902197 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12902197 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12902197 | pubmed:volume | 190 | lld:pubmed |
| pubmed-article:12902197 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12902197 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12902197 | pubmed:pagination | 262-71 | lld:pubmed |
| pubmed-article:12902197 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12902197 | pubmed:meshHeading | pubmed-meshheading:12902197... | lld:pubmed |
| pubmed-article:12902197 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12902197 | pubmed:articleTitle | 4-Methylthioamphetamine-induced hyperthermia in mice: influence of serotonergic and catecholaminergic pathways. | lld:pubmed |
| pubmed-article:12902197 | pubmed:affiliation | ICETA/CEQUP, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal. helenacarmo@mail.ff.up.pt | lld:pubmed |
| pubmed-article:12902197 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12902197 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12902197 | lld:pubmed |
