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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-8-6
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pubmed:abstractText |
4-Methylthioamphetamine (4-MTA), also known as p-methylthioamphetamine, is a new amphetamine derivative which in humans has been increasingly associated with severe intoxications and several deaths. As hyperthermia is considered to be one of the most life-threatening acute physiological consequences of amphetamine-related intoxications, it was our aim to determine whether 4-MTA induces changes in body temperature in a mouse model. Accordingly, we measured the subcutaneous temperature after acute administration of 4-MTA in CD1 mice. Because hyperthermia seems to result from the central and peripheral actions of catecholamines and serotonin (5-hydroxytriptamine or 5-HT), we also investigated the possible interactions of some catecholaminergic and serotonergic receptor blockers and the inhibition of monoamine oxidase (MAO) with this effect. 4-MTA induced hyperthermia in CD1 mice. Blockade of the 5-HT receptors with methysergide and MAO inhibition with pargyline resulted in the potentiation of the 4-MTA-induced hyperthermic effect. Blockade of the alpha(1)-adrenergic receptors with prazosin completely reverted the 4-MTA-induced hyperthermia while with the beta-adrenergic receptor blocker dl-propranolol this reversal was not complete. Blockade of the alpha(2)-adrenergic receptors with yohimbine had no effect on the hyperthermia induced by 4-MTA. These results suggest that 4-MTA-induced hyperthermia is highly influenced by the catecholaminergic and serotonergic receptor activation and the MAO activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-methylthioamphetamine,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Amphetamines,
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/Methysergide,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pargyline,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0041-008X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
262-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12902197-Adrenergic alpha-Antagonists,
pubmed-meshheading:12902197-Amphetamines,
pubmed-meshheading:12902197-Animals,
pubmed-meshheading:12902197-Body Temperature,
pubmed-meshheading:12902197-Catecholamines,
pubmed-meshheading:12902197-Hyperthermia, Induced,
pubmed-meshheading:12902197-Male,
pubmed-meshheading:12902197-Methysergide,
pubmed-meshheading:12902197-Mice,
pubmed-meshheading:12902197-Mice, Inbred Strains,
pubmed-meshheading:12902197-Monoamine Oxidase,
pubmed-meshheading:12902197-Monoamine Oxidase Inhibitors,
pubmed-meshheading:12902197-Pargyline,
pubmed-meshheading:12902197-Prazosin,
pubmed-meshheading:12902197-Receptors, Adrenergic,
pubmed-meshheading:12902197-Receptors, Serotonin,
pubmed-meshheading:12902197-Serotonin,
pubmed-meshheading:12902197-Serotonin Antagonists
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pubmed:year |
2003
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pubmed:articleTitle |
4-Methylthioamphetamine-induced hyperthermia in mice: influence of serotonergic and catecholaminergic pathways.
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pubmed:affiliation |
ICETA/CEQUP, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal. helenacarmo@mail.ff.up.pt
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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