Linked Life Data

12902022

Source:http://linkedlifedata.com/resource/pubmed/id/12902022

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-8-6
pubmed:abstractText
In heatstroke related symptoms in streptozotocin-induced diabetic rats (STZ-diabetic rats) exposed to a high temperature (43 degrees C) for 60 min, like that in normal rats, the high colon temperature and the decreases of mean arterial pressure, heart rate and cerebral blood flow were abolished by MK-801, the NMDA receptor antagonist. Also, striatal glutamate was markedly released in both animals by this exposure while the release was higher and the survival time was shorter in STZ-diabetic rats than in normal rats. After insulin treatment, like that by MK-801 pretreatment, the striatal glutamate and the incidence of heatstroke in STZ-diabetic rats were markedly reduced. Therefore, heatstroke was more easily induced via the elevated striatal glutamate in STZ-diabetic rats by high temperature exposure. Insulin treatment seems helpful in the prevention of heatstroke in STZ-diabetic rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
348
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-80
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Role of striatal glutamate in heatstroke-induced damage in streptozotocin-induced diabetic rats.
pubmed:affiliation
Department of Physiology, National Yang-Ming University, Taipei 11221, Taiwan.
pubmed:publicationType
Journal Article