| pubmed-article:12898595 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C0349532 | lld:lifeskim |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C0288472 | lld:lifeskim |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C0173532 | lld:lifeskim |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C1850900 | lld:lifeskim |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C0249197 | lld:lifeskim |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C1420626 | lld:lifeskim |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:12898595 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:12898595 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12898595 | pubmed:dateCreated | 2003-8-4 | lld:pubmed |
| pubmed-article:12898595 | pubmed:abstractText | Cyclin D3 plays a pivotal role in controlling the physiological progression from the G1 to the S phase of the cell cycle. Recent data suggest that cyclin D3 may be deregulated in extranodal non-Hodgkin's lymphomas (NHLs) as a consequence of the t(6;14)(p21.1;q32.3) translocation. The present study investigated for the first time by dual-colour fluorescence in situ hybridization (FISH) on interphase nuclei and immunohistochemistry the prevalence of the t(6;14) translocation and cyclin D3 immunoreactivity (IR) in a series of 29 stage I-IIE primary gastric NHLs (PGLs). No case showed the t(6;14) translocation. However, in five (17.2%) cases (two extranodal marginal zone lymphomas of MALT type, LGM; one diffuse large-cell lymphoma with a MALT component, DLCLM; and two diffuse large-cell lymphomas without a MALT component, DLCL), three to four cyclin D3 signals were detected by FISH. Co-hybridization with probes specific for the centromeric region and long arm of chromosome 6 indicated trisomy in one case (DLCL), whereas in the remaining four cases the pattern was highly suggestive of the presence of an isochromosome 6p. One (12.5%) case of LGM, six (75%) cases of DLCLM, and seven (53.8%) cases of DLCL (p = 0.0378) were immunoreactive for cyclin D3. Cyclin D3 IR was detected in two (40%) of the five cases with extra cyclin D3 signals and in 12 of the remaining 24 cases (50%, p = 1.000). These results suggest that the t(6;14) may represent a rare event in the pathogenesis of PGL and that cyclin D3 deregulation is most likely the result of epigenetic mechanisms. | lld:pubmed |
| pubmed-article:12898595 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12898595 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12898595 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12898595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12898595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12898595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12898595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12898595 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12898595 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12898595 | pubmed:issn | 0022-3417 | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:PonzoniMauril... | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:CapellaCarloC | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:MottaTeresioT | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:VialeGiuseppe... | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:PruneriGianca... | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:AndreolaSalva... | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:NeriAntoninoA | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:PozziBarbaraB | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:FerreriAndres... | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:FabrisSoniaS | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:FasaniRoberta... | lld:pubmed |
| pubmed-article:12898595 | pubmed:author | pubmed-author:Del... | lld:pubmed |
| pubmed-article:12898595 | pubmed:copyrightInfo | Copyright 2003 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:12898595 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12898595 | pubmed:volume | 200 | lld:pubmed |
| pubmed-article:12898595 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12898595 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12898595 | pubmed:pagination | 596-601 | lld:pubmed |
| pubmed-article:12898595 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12898595 | pubmed:meshHeading | pubmed-meshheading:12898595... | lld:pubmed |
| pubmed-article:12898595 | pubmed:meshHeading | pubmed-meshheading:12898595... | lld:pubmed |
| pubmed-article:12898595 | pubmed:meshHeading | pubmed-meshheading:12898595... | lld:pubmed |
| pubmed-article:12898595 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12898595 | pubmed:articleTitle | Immunoreactivity for cyclin D3 is frequently detectable in high-grade primary gastric lymphomas in the absence of the t(6;14)(p21.1;q32.3) chromosomal translocation. | lld:pubmed |
| pubmed-article:12898595 | pubmed:affiliation | Divisions of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy. | lld:pubmed |
| pubmed-article:12898595 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12898595 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:12898595 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12898595 | lld:pubmed |
