Source:http://linkedlifedata.com/resource/pubmed/id/12898595
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2003-8-4
|
| pubmed:abstractText |
Cyclin D3 plays a pivotal role in controlling the physiological progression from the G1 to the S phase of the cell cycle. Recent data suggest that cyclin D3 may be deregulated in extranodal non-Hodgkin's lymphomas (NHLs) as a consequence of the t(6;14)(p21.1;q32.3) translocation. The present study investigated for the first time by dual-colour fluorescence in situ hybridization (FISH) on interphase nuclei and immunohistochemistry the prevalence of the t(6;14) translocation and cyclin D3 immunoreactivity (IR) in a series of 29 stage I-IIE primary gastric NHLs (PGLs). No case showed the t(6;14) translocation. However, in five (17.2%) cases (two extranodal marginal zone lymphomas of MALT type, LGM; one diffuse large-cell lymphoma with a MALT component, DLCLM; and two diffuse large-cell lymphomas without a MALT component, DLCL), three to four cyclin D3 signals were detected by FISH. Co-hybridization with probes specific for the centromeric region and long arm of chromosome 6 indicated trisomy in one case (DLCL), whereas in the remaining four cases the pattern was highly suggestive of the presence of an isochromosome 6p. One (12.5%) case of LGM, six (75%) cases of DLCLM, and seven (53.8%) cases of DLCL (p = 0.0378) were immunoreactive for cyclin D3. Cyclin D3 IR was detected in two (40%) of the five cases with extra cyclin D3 signals and in 12 of the remaining 24 cases (50%, p = 1.000). These results suggest that the t(6;14) may represent a rare event in the pathogenesis of PGL and that cyclin D3 deregulation is most likely the result of epigenetic mechanisms.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-3417
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| pubmed:author |
pubmed-author:AndreolaSalvatoreS,
pubmed-author:CapellaCarloC,
pubmed-author:Del CurtoBarbaraB,
pubmed-author:FabrisSoniaS,
pubmed-author:FasaniRobertaR,
pubmed-author:FerreriAndres J MAJ,
pubmed-author:MottaTeresioT,
pubmed-author:NeriAntoninoA,
pubmed-author:PonzoniMaurilioM,
pubmed-author:PozziBarbaraB,
pubmed-author:PruneriGiancarloG,
pubmed-author:VialeGiuseppeG
|
| pubmed:copyrightInfo |
Copyright 2003 John Wiley & Sons, Ltd.
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| pubmed:issnType |
Print
|
| pubmed:volume |
200
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
596-601
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:12898595-Adult,
pubmed-meshheading:12898595-Aged,
pubmed-meshheading:12898595-Aged, 80 and over,
pubmed-meshheading:12898595-Chromosomes, Human, Pair 14,
pubmed-meshheading:12898595-Chromosomes, Human, Pair 6,
pubmed-meshheading:12898595-Cyclin D3,
pubmed-meshheading:12898595-Cyclins,
pubmed-meshheading:12898595-Female,
pubmed-meshheading:12898595-Humans,
pubmed-meshheading:12898595-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12898595-Lymphoma, B-Cell,
pubmed-meshheading:12898595-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:12898595-Lymphoma, Non-Hodgkin,
pubmed-meshheading:12898595-Male,
pubmed-meshheading:12898595-Middle Aged,
pubmed-meshheading:12898595-Neoplasm Proteins,
pubmed-meshheading:12898595-Stomach Neoplasms,
pubmed-meshheading:12898595-Translocation, Genetic
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Immunoreactivity for cyclin D3 is frequently detectable in high-grade primary gastric lymphomas in the absence of the t(6;14)(p21.1;q32.3) chromosomal translocation.
|
| pubmed:affiliation |
Divisions of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|