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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-9-8
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pubmed:abstractText |
Type 1 diabetes mellitus is an autoimmune disease characterized by dysfunction and destruction of the pancreatic beta cells. Interleukin-1beta (IL-1beta) has been reported to cause suppression of insulin secretion from pancreatic islets via induction of inducible nitric oxide synthase (iNOS) followed by nitric oxide (NO) production. In this study, we investigated the effects of inhibition of iNOS on pancreatic beta-cell dysfunction in non-obese diabetic (NOD) mice and IL-1beta-treated isolated rat pancreatic islets using a novel specific inhibitor, ONO-1714.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/7-chloro-3-imino-5-methyl-2-azabicyc...,
http://linkedlifedata.com/resource/pubmed/chemical/Amidines,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Heterocyclic Compounds, 2-Ring,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrites,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/omega-N-Methylarginine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1228-33
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12898012-Amidines,
pubmed-meshheading:12898012-Animals,
pubmed-meshheading:12898012-Base Sequence,
pubmed-meshheading:12898012-Blood Glucose,
pubmed-meshheading:12898012-Cell Culture Techniques,
pubmed-meshheading:12898012-DNA Primers,
pubmed-meshheading:12898012-Female,
pubmed-meshheading:12898012-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12898012-Heterocyclic Compounds, 2-Ring,
pubmed-meshheading:12898012-Humans,
pubmed-meshheading:12898012-Insulin,
pubmed-meshheading:12898012-Interleukin-1,
pubmed-meshheading:12898012-Islets of Langerhans,
pubmed-meshheading:12898012-Male,
pubmed-meshheading:12898012-Mice,
pubmed-meshheading:12898012-Mice, Inbred NOD,
pubmed-meshheading:12898012-Nitric Oxide,
pubmed-meshheading:12898012-Nitric Oxide Synthase,
pubmed-meshheading:12898012-Nitric Oxide Synthase Type II,
pubmed-meshheading:12898012-Nitrites,
pubmed-meshheading:12898012-Rats,
pubmed-meshheading:12898012-Rats, Sprague-Dawley,
pubmed-meshheading:12898012-Recombinant Proteins,
pubmed-meshheading:12898012-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12898012-Transcription, Genetic,
pubmed-meshheading:12898012-omega-N-Methylarginine
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pubmed:year |
2003
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pubmed:articleTitle |
Suppressive effects of a selective inducible nitric oxide synthase (iNOS) inhibitor on pancreatic beta-cell dysfunction.
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pubmed:affiliation |
Department of Endocrinology and Diabetology, Nagoya University School of Medicine, Showa-ku, Nagoya, Japan.
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pubmed:publicationType |
Journal Article
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