Source:http://linkedlifedata.com/resource/pubmed/id/12896824
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-8-4
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| pubmed:abstractText |
Pre-eclampsia, one of the main complications in pregnancy, is characterised by shallow cytotrophoblast invasion of decidua as well as by vascular endothelial cell dysfunction, leading to a poor perfusion of placenta. A striking feature of pre-eclamptic pregnancies is that expression of HLA-G protein is reduced in term placentas compared with normal pregnancy. How such HLA-G deficient expression may be related to the pre-eclamptic pathology is unknown. Here, we review the major structural characteristics of HLA-G and some of its functions that have been recently characterised. Soluble HLA-G1 isoform down-regulates both CD8(+) and CD4(+) T cell reactivity. HLA-G also modulates innate immunity by binding to several NK and/or decidual receptors, inducing particular cytokine secretion. HLA-G was shown to be less susceptible to human cytomegalovirus-derived US protein down-modulation. Finally, soluble HLA-G1 down-regulates endothelial cell proliferation and migration. In view of these different HLA-G properties, we will briefly discuss how defective HLA-G function may contribute to the low trophoblast invasion and vascular abnormalities observed in pre-eclamptic placentas.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0165-0378
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
59
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
219-34
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12896824-Animals,
pubmed-meshheading:12896824-Apoptosis,
pubmed-meshheading:12896824-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12896824-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12896824-Cell Movement,
pubmed-meshheading:12896824-Cytomegalovirus,
pubmed-meshheading:12896824-Down-Regulation,
pubmed-meshheading:12896824-Endothelium, Vascular,
pubmed-meshheading:12896824-Female,
pubmed-meshheading:12896824-HLA Antigens,
pubmed-meshheading:12896824-HLA-G Antigens,
pubmed-meshheading:12896824-Histocompatibility Antigens Class I,
pubmed-meshheading:12896824-Humans,
pubmed-meshheading:12896824-Immunity, Innate,
pubmed-meshheading:12896824-Killer Cells, Natural,
pubmed-meshheading:12896824-Mice,
pubmed-meshheading:12896824-Placenta,
pubmed-meshheading:12896824-Pre-Eclampsia,
pubmed-meshheading:12896824-Pregnancy,
pubmed-meshheading:12896824-Trophoblasts
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| pubmed:year |
2003
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| pubmed:articleTitle |
HLA-G, pre-eclampsia, immunity and vascular events.
|
| pubmed:affiliation |
INSERM U563, Centre de Physiopathologie Toulouse-Purpan, Bât. A, Hôpital Purpan, Cedex 3, 31059 Toulouse, France. phil.lb@toulouse.inserm.fr
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|