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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3A
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pubmed:dateCreated |
2003-8-4
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pubmed:abstractText |
The ETS-family of proteins consists of over 30 members that regulate the growth, differentiation and survival of both normal and tumor cells. How specificity is achieved within this family remains largely unresolved. One mechanism for attaining specificity is through the action of signaling pathways on specific family members. For example, Ets-2 is an activator modulated by ras-dependent phosphorylation of a single residue in the conserved pointed domain of this factor. We hypothesized that phosphorylation of the pointed domain regulates the proteins that can interact with ets-2 in the cell nucleus, resulting in regulation of target genes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ERF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ets2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Protein c-ets-2,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Zmynd11 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2173-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12894593-3T3 Cells,
pubmed-meshheading:12894593-Animals,
pubmed-meshheading:12894593-Carrier Proteins,
pubmed-meshheading:12894593-DNA-Binding Proteins,
pubmed-meshheading:12894593-Gene Expression Regulation,
pubmed-meshheading:12894593-Genes, BRCA1,
pubmed-meshheading:12894593-Genes, Reporter,
pubmed-meshheading:12894593-Histone Deacetylases,
pubmed-meshheading:12894593-Mice,
pubmed-meshheading:12894593-Nuclear Proteins,
pubmed-meshheading:12894593-Phosphorylation,
pubmed-meshheading:12894593-Protein Structure, Tertiary,
pubmed-meshheading:12894593-Proto-Oncogene Protein c-ets-2,
pubmed-meshheading:12894593-Proto-Oncogene Proteins,
pubmed-meshheading:12894593-Repressor Proteins,
pubmed-meshheading:12894593-Signal Transduction,
pubmed-meshheading:12894593-Trans-Activators,
pubmed-meshheading:12894593-Transcription Factors,
pubmed-meshheading:12894593-Transfection
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pubmed:articleTitle |
Ets-2 interacts with co-repressor BS69 to repress target gene expression.
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pubmed:affiliation |
Department of Molecular Genetics, Comprehensive Cancer Center, Ohio State University, 484 W. 12th Ave., Columbus, OH 43210, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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