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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3B
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pubmed:dateCreated |
2003-8-4
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pubmed:abstractText |
Novobiocin was shown to sensitize cancer cells to etoposide and alkylating agents. Human breast carcinoma cells exposed to topotecan (MCF7/TPT300 cells) developed resistance to both mitoxantrone and topotecan. An ATP-binding cassette family protein BCRP/MXR/ABCP was overexpressed in MCF7/TPT300 cells. In addition, topotecan efflux was markedly enhanced in the resistant cells. To investigate the possibility that novobiocin may enhance cytotoxicity in BCRP/MXR/ABCP overexpressing cells, we exposed MCF7/TPT300 cells to novobiocin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2519-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12894535-ATP-Binding Cassette Transporters,
pubmed-meshheading:12894535-Anti-Bacterial Agents,
pubmed-meshheading:12894535-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:12894535-Breast Neoplasms,
pubmed-meshheading:12894535-Drug Resistance, Neoplasm,
pubmed-meshheading:12894535-Drug Synergism,
pubmed-meshheading:12894535-Humans,
pubmed-meshheading:12894535-Mitoxantrone,
pubmed-meshheading:12894535-Neoplasm Proteins,
pubmed-meshheading:12894535-Novobiocin,
pubmed-meshheading:12894535-Topotecan,
pubmed-meshheading:12894535-Tumor Cells, Cultured
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pubmed:articleTitle |
Novobiocin sensitizes BCRP/MXR/ABCP overexpressing topotecan-resistant human breast carcinoma cells to topotecan and mitoxantrone.
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pubmed:affiliation |
Department of Oncology, Cancer Research Center, National Taiwan University Hospital, Medical College, National Taiwan University, Taipei, Taiwan. chjyang@ha.mc.ntu.edu.tw
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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