Thioguanine (6-TG) has been studied as an alternative thiopurine in inflammatory bowel disease (IBD). Short-term safety and efficacy data were favorable. Experience with 6-TG in patients with acute lymphoblastic leukemia raised long-term safety concerns when implicated in nodular regenerative hyperplasia (NRH) of the liver and portal hypertension. The aim of this study was to describe the association between 6-TG and NRH in IBD.
Pediatric Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 1165W, Los Angeles, California 90048, USA. dubinskym@csmc.edu