Linked Life Data

12890768

Source:http://linkedlifedata.com/resource/pubmed/id/12890768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2003-7-31
pubmed:abstractText
Post-training infusions of drugs, including noradrenergic agonists and antagonists, into the basolateral amygdala (BLA) influence the consolidation of memory for training in several tasks, including inhibitory avoidance. There is, however, conflicting evidence concerning whether post-training intra-BLA drug infusions modulate the consolidation of contextual fear conditioning (CFC). In the present study, norepinephrine (NE) was infused bilaterally into the BLA of male Sprague Dawley rats immediately after training on two CFC tasks: a Y-maze and a straight alley. Post-training intra-BLA infusions enhanced memory of CFC training in the Y-maze, as assessed by percentage of time spent freezing and shock arm entrance latencies. Post-training intra-BLA infusions of NE enhanced 48 hr retention of CFC training in the straight alley, as assessed by shock compartment entrance latencies and the number of shocks required to learn to avoid entering the shock compartment. These findings indicate that the consolidation of memory for CFC, like that for inhibitory avoidance training, is influenced by post-training neuromodulatory influences within the BLA. Thus, the findings provide additional evidence consistent with the hypothesis that the BLA has a general role in modulating memory consolidation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
30
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6754-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Post-training intra-basolateral amygdala infusions of norepinephrine enhance consolidation of memory for contextual fear conditioning.
pubmed:affiliation
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-3800, USA. rlalumie@uci.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.