Source:http://linkedlifedata.com/resource/pubmed/id/12889669
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
2003-7-31
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pubmed:abstractText |
In 2001 we identified a new inborn error of metabolism caused by a defect in the X-linked creatine transporter SLC6A8 gene mapped at Xq28 (SLC6A8 deficiency, McKusick 300352). An X-linked creatine transporter defect was presumed because of (1) the absence of creatine in the brain as indicated by proton magnetic resonance spectroscopy (MRS); (2) the elevated creatine levels in urine and normal guanidinoacetate levels in plasma, ruling out a creatine biosynthesis defect; (3) the absence of an improvement on creatine supplementation; and (4) the fact that the pedigree suggested an X-linked disease. Our hypothesis was proved by the presence of a hemizygous nonsense mutation in the male index patient and by the impaired creatine uptake by cultured fibroblasts. Currently, at least 7 unrelated families (13 male patients and 13 carriers) with a SLC6A8 deficiency have been identified. Four families come from one metropolitan area. This suggests that SLC6A8 deficiency may have a relatively high incidence. The hallmarks of the disorder are X-linked mental retardation, expressive speech and language delay, epilepsy, developmental delay and autistic behaviour. In approximately 50% of the female carriers, learning disabilities of varying degrees have been noted.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Creatine,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Plasma Membrane Neurotransmitter...,
http://linkedlifedata.com/resource/pubmed/chemical/SLC6A8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/creatine transporter
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pubmed:status |
MEDLINE
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pubmed:issn |
0141-8955
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
309-18
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12889669-Biological Transport,
pubmed-meshheading:12889669-Chromosomes, Human, X,
pubmed-meshheading:12889669-Creatine,
pubmed-meshheading:12889669-Female,
pubmed-meshheading:12889669-Genetic Linkage,
pubmed-meshheading:12889669-Humans,
pubmed-meshheading:12889669-Male,
pubmed-meshheading:12889669-Membrane Transport Proteins,
pubmed-meshheading:12889669-Metabolism, Inborn Errors,
pubmed-meshheading:12889669-Nerve Tissue Proteins,
pubmed-meshheading:12889669-Plasma Membrane Neurotransmitter Transport Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
X-linked creatine transporter defect: an overview.
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pubmed:affiliation |
Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands. g.salomons@vumc.nl
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pubmed:publicationType |
Journal Article,
Review
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