Linked Life Data

12887723

Source:http://linkedlifedata.com/resource/pubmed/id/12887723

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-7-30
pubmed:abstractText
This article summarizes the clinical evidence for low-density lipoprotein (LDL) apheresis to improve prognosis of patients with coronary heart disease. Regarding clinical events or angiographic parameters, most trials have revealed favorable effects on coronary artery disease. In the studies with a clinical endpoint, approximately 50% reduction in incidence of major coronary events was achieved by LDL apheresis. Similarly, in the studies with a angiographic parameter, coronary atherosclerosis was suppressed or regressed by LDL apheresis. The mechanisms of these effects by LDL apheresis are attributed to improvement in coronary flow reserve, which is dependent upon increases in hemo-rheological factor, nitric oxide, vasoactive substances or decrease of oxidized LDL. These new insights into mechanisms will expand the indication of LDL apheresis to other pathophysiological conditions of coronary artery disease and other disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1744-9979
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
408-12
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Low-density lipoprotein apheresis in the prevention of recurrent coronary heart disease: a review.
pubmed:affiliation
Second Department of Internal Medicine, School of Medicine, University of Occupational Environmental Health, Yahatanishi-ku, Kitakyushu, Japan. h-tasaki@med.uoeh-u.ac.jp
pubmed:publicationType
Journal Article, Review