Linked Life Data

12887153

Source:http://linkedlifedata.com/resource/pubmed/id/12887153

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-7-30
pubmed:abstractText
Of four fractions (CH2Cl2, EtOAc, BuOH and H2O) from mustard leaf (Brassica juncea), the EtOAc fraction showed the strongest inhibitory effects, which were concentration-dependent, on the formation of advanced glycation end products and free radical-mediated protein damage in an in vitro system, indicating that this fraction has a potential protective role against diabetes and/or its complications. Based on these results, we carried out an in vivo study to determine whether the EtOAc fraction protected against diabetic oxidative stress induced by streptozotocin. Oral administration of the EtOAc fraction at doses of 50 and 200 mg/kg body weight/d for 10 d reduced the serum levels of glucose and glycosylated protein, implying that the impaired glucose metabolism due to diabetes had been ameliorated. In addition, the EtOAc fraction significantly reduced the thiobarbituric acid-reactive substance levels of serum and hepatic and renal mitochondria. Furthermore, the elevated levels of superoxide and nitrite/nitrate were reduced in a dose-dependent manner by oral administration of the EtOAc fraction. These findings suggest that the EtOAc fraction from mustard leaf might be beneficial in attenuating the damage caused by oxidative stress involved in diabetes and its complications.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0301-4800
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-93
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Protective effects of mustard leaf (Brassica juncea) against diabetic oxidative stress.
pubmed:affiliation
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan. yokozawa@ms.toyama-mpu.ac.jp
pubmed:publicationType
Journal Article, In Vitro