Linked Life Data

12885592

Source:http://linkedlifedata.com/resource/pubmed/id/12885592

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-7-29
pubmed:abstractText
Oxidized lipoproteins are implicated in atherosclerosis, and some antioxidants attenuate the disease in animals. Coenzyme Q(10) (CoQ(10)) in its reduced form, ubiquinol-10, effectively inhibits lipoprotein oxidation in vitro and in vivo; CoQ(10) supplements also inhibit atherosclerosis in apolipoprotein E gene knockout (apoE-/-) mice. Here we tested the effect of dietary CoQ(10) supplements on intimal proliferation and lipoprotein lipid oxidation in balloon-injured, hypercholesterolemic rabbits. Compared to nonsupplemented chow, CoQ(10) supplementation (0.5% and 1.0%, w/w) significantly increased the plasma concentration of CoQ(10) and the resistance of plasma lipids to ex vivo oxidation. CoQ(10) supplements also increased the content of CoQ(10) in the aorta and liver, but not in the brain, skeletal muscle, kidney, and heart. Surprisingly, CoQ(10) supplementation at 1% increased the aortic concentrations of all lipids, particularly triacylglycerols, although it significantly inhibited the proportion of triacylglycerols present as hydroperoxides by > 80%. The observed increase in vessel wall lipid content was reflected in elevated plasma concentrations of cholesterol, cholesteryl esters and triacylglycerols, and hepatic levels of mRNA for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. CoQ(10) supplements did not attenuate lesion formation, assessed by the intima-to-media ratio of injured aortic vessels. Thus, like in apoE-/- mice, a high dose of supplemented CoQ(10) inhibits lipid oxidation in the artery wall of balloon-injured, hypercholesterolemic rabbits. However, unlike its antiatherosclerosis activity in the mice, CoQ(10) does not inhibit intimal hyperplasia in rabbits, thereby dissociating this disease process from lipid oxidation in the vessel wall.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0891-5849
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
300-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12885592-Animals, pubmed-meshheading:12885592-Antioxidants, pubmed-meshheading:12885592-Aorta, pubmed-meshheading:12885592-Cholesterol, pubmed-meshheading:12885592-Chromatography, Gel, pubmed-meshheading:12885592-Coenzymes, pubmed-meshheading:12885592-Dietary Supplements, pubmed-meshheading:12885592-Dose-Response Relationship, Drug, pubmed-meshheading:12885592-Free Radicals, pubmed-meshheading:12885592-Hydroxymethylglutaryl CoA Reductases, pubmed-meshheading:12885592-Lipid Metabolism, pubmed-meshheading:12885592-Male, pubmed-meshheading:12885592-Oxygen, pubmed-meshheading:12885592-RNA, Messenger, pubmed-meshheading:12885592-Rabbits, pubmed-meshheading:12885592-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:12885592-Time Factors, pubmed-meshheading:12885592-Tissue Distribution, pubmed-meshheading:12885592-Ubiquinone
pubmed:year
2003
pubmed:articleTitle
Coenzyme Q(10) supplementation inhibits aortic lipid oxidation but fails to attenuate intimal thickening in balloon-injured New Zealand white rabbits.
pubmed:affiliation
Biochemistry Group, The Heart Research Institute, Camperdown, New South Wales, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't