Linked Life Data

12883238

Source:http://linkedlifedata.com/resource/pubmed/id/12883238

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2003-7-28
pubmed:abstractText
Cutaneous marginal zone B-cell lymphoma is a recently proposed entity and constitutes a cutaneous counterpart of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). Borrelia burgdorferi infection has been suggested as a possible causative agent in European cutaneous cases of marginal zone B-cell lymphoma, whereas API2-MALT1 fusion and BCL10 mutation are highly associated with MALT lymphoma. Aberrant nuclear BCL10 expression may be closely correlated with API2-MALT1 fusion in gastric and pulmonary MALT lymphomas. We examined 24 Asian cases of cutaneous marginal zone B-cell lymphoma for B. burgdorferi involvement, API2-MALT1 fusion, BCL10 cellular expression, and BCL10 mutation. Neither Borrelia DNA nor API2-MALT1 fusion transcript was detected. Nuclear BCL10 expression was evident in tumor cells of 11 of 24 cases, although BCL10 mutation was found in one case only. Clinicopathologically, nuclear BCL10 was more frequently expressed in macroscopically nodular lesions than in plaques or papules (p = 0.0031). These data suggest that 1) B. burgdorferi infection may not play an important role in developing cutaneous marginal zone B-cell lymphoma in Asian cases, 2) neither API2-MALT1 fusion nor BCL10 mutation is closely associated with the pathogenesis, 3) aberrant nuclear BCL10 may frequently be expressed in the absence of these genetic abnormalities, and 4) nuclear BCL10 expression may be clinically important because it was observed in locally aggressive tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0147-5185
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1061-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12883238-Adaptor Proteins, Signal Transducing, pubmed-meshheading:12883238-Adult, pubmed-meshheading:12883238-Aged, pubmed-meshheading:12883238-Aged, 80 and over, pubmed-meshheading:12883238-Borrelia burgdorferi, pubmed-meshheading:12883238-Carrier Proteins, pubmed-meshheading:12883238-Cell Nucleus, pubmed-meshheading:12883238-DNA, Neoplasm, pubmed-meshheading:12883238-Female, pubmed-meshheading:12883238-Humans, pubmed-meshheading:12883238-Immunoenzyme Techniques, pubmed-meshheading:12883238-Lymphoma, B-Cell, pubmed-meshheading:12883238-Lymphoma, B-Cell, Marginal Zone, pubmed-meshheading:12883238-Male, pubmed-meshheading:12883238-Middle Aged, pubmed-meshheading:12883238-Oncogene Proteins, Fusion, pubmed-meshheading:12883238-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:12883238-Skin Neoplasms
pubmed:year
2003
pubmed:articleTitle
Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathologic study of 24 asian cases.
pubmed:affiliation
Department of Pathology, Nagoya City Unviersity Medical School, Nagoya, Japan. hinagaki@med.nagoya-cu.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't