Linked Life Data

12881638

Source:http://linkedlifedata.com/resource/pubmed/id/12881638

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-7-25
pubmed:databankReference
pubmed:abstractText
Infection with cytomegalovirus (CMV) is persistent, even in the normal host. Periodic viral reactivation may have serious consequences, particularly if the infected individual is immunosuppressed, or pregnant. A number of CMV genes appear to contribute to the phenomena of evasion of host immune clearance, including homologs of cellular immune effector proteins, such as chemokines (CKs), chemokine receptor-like G protein-coupled receptors (GPCRs), and MHC class I molecules. To examine whether the guinea pig cytomegalovirus (GPCMV) encodes homologs of these cellular immunoregulatory genes, regions of the viral genome were sequenced and analyzed for the presence of conserved and novel open reading frames (ORFs) with potential homology to GPCR and CK proteins. A region in the Hind III 'D' region of the genome was identified which had strong identity to multiple beta (CC) chemokines, particularly members of the macrophage inflammatory protein 1 (MIP-1) family. Northern blot analysis indicated that this region of the genome was transcriptionally active, encoding a transcript of 1.7 kbp, which was synthesized with 'late' gene kinetics. This is the first identification of a CK gene encoded by GPCMV, and adds to the growing list of putative CMV immunomodulatory genes which appear to have been transduced from the host genome during the co-evolution of host and pathogen.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0920-8569
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
A novel CC-chemokine homolog encoded by guinea pig cytomegalovirus.
pubmed:affiliation
Department of Biological Sciences, Xavier University, Cincinnati, OH, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't