Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2003-8-6
pubmed:abstractText
Pulmonary artery (PA) hypertension was studied in a chronic hypoxic-pulmonary hypertension model (7-21 days) in the rat. Increase in PA pressure (measured by catheterism), cardiac right ventricle hypertrophy (determined by echocardiography), and PA remodeling (evaluated by histology) were almost entirely prevented after oral dehydroepiandrosterone (DHEA) administration (30 mg/kg every alternate day). Furthermore, in hypertensive rats, oral administration, or intravascular injection (into the jugular vein) of DHEA rapidly decreased PA hypertension. In PA smooth muscle cells, DHEA reduced the level of intracellular calcium (measured by microspectrofluorimetry). The effect of DHEA appears to involve a large conductance Ca2+-activated potassium channel (BKCa)-dependent stimulatory mechanism, at both function and expression levels (isometric contraction and Western blot), via a redox-dependent pathway. Voltage-gated potassium (Kv) channels also may be involved because the antagonist 4-amino-pyridine blocked part of the DHEA effect. The possible pathophysiological and therapeutic significance of the results is discussed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-10101006, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-10480450, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-10760294, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-10849663, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-11356790, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-11420297, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-11590838, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-11787951, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-11907187, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-11922912, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-12006444, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-12527688, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-12765434, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-7542182, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-8020277, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-8304521, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-8546869, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-8546871, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-8546872, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-8943284, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-9142852, http://linkedlifedata.com/resource/pubmed/commentcorrection/12878719-9362476
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9488-93
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:12878719-Adjuvants, Immunologic, pubmed-meshheading:12878719-Administration, Oral, pubmed-meshheading:12878719-Animals, pubmed-meshheading:12878719-Anoxia, pubmed-meshheading:12878719-Blotting, Western, pubmed-meshheading:12878719-Calcium, pubmed-meshheading:12878719-Calcium Channels, pubmed-meshheading:12878719-Dehydroepiandrosterone, pubmed-meshheading:12878719-Dose-Response Relationship, Drug, pubmed-meshheading:12878719-Echocardiography, pubmed-meshheading:12878719-Hemodynamics, pubmed-meshheading:12878719-Hypertension, Pulmonary, pubmed-meshheading:12878719-Lung, pubmed-meshheading:12878719-Male, pubmed-meshheading:12878719-Myocardial Contraction, pubmed-meshheading:12878719-Myocardium, pubmed-meshheading:12878719-Oxidation-Reduction, pubmed-meshheading:12878719-Potassium Channels, pubmed-meshheading:12878719-Pressure, pubmed-meshheading:12878719-Rats, pubmed-meshheading:12878719-Rats, Wistar
pubmed:year
2003
pubmed:articleTitle
Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale, EMI 0356, Physiologie Cellulaire Respiratoire, Université de Bordeaux II, 146, Rue Léo Saignat, 33076 Bordeaux Cedex, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't