| pubmed-article:12878703 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C1419850 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C0206249 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12878703 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12878703 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:12878703 | pubmed:dateCreated | 2003-7-24 | lld:pubmed |
| pubmed-article:12878703 | pubmed:abstractText | The maintenance of long-term potentiation (LTP) depends on alteration of gene transcription. By screening a subtracted cDNA library that is enriched in upregulated transcripts in rat hippocampus 3 hr after Schaffer-CA1 LTP induction in vivo, we identified a neural growth-associated protein SCG10 (superior cervical ganglia clone 10) gene. The semiquantitative reverse transcription-PCR and Northern blot experiments confirmed that SCG10 mRNA levels were elevated in tetanized rat hippocampi compared with those of sham controls that received only low-frequency stimulation. Both 1 and 2 kb forms of SCG10 mRNAs contributed to the increased expression. Using a riboprobe with a sequence specific to the 3'-untranslated region of rat SCG10 mRNA, in situ hybridization further revealed a significant increase of the SCG10 mRNA 2 kb form in the ipsilateral CA3 and CA1 regions of LTP animals. In addition, we systemically injected the competitive NMDA receptor antagonist d,l-3[(+/-)-2-carboxypiperazine-4-yl]-propyl-1-phosphonic acid (CPP) to determine whether the alteration of SCG10 expression depends on NMDA receptor activation or tetanus alone. Administration of CPP 1 hr before tetanus completely blocked LTP induction and the increase of SCG10 mRNA levels. Thus, these results suggest that the transcription of SCG10 in vivo is regulated by long-lasting synaptic activity and may contribute to the maintenance of long-term synaptic plasticity via a presynaptic remodeling mechanism. | lld:pubmed |
| pubmed-article:12878703 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12878703 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12878703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878703 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12878703 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12878703 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:12878703 | pubmed:author | pubmed-author:DerrickBrian... | lld:pubmed |
| pubmed-article:12878703 | pubmed:author | pubmed-author:MartinezJoe... | lld:pubmed |
| pubmed-article:12878703 | pubmed:author | pubmed-author:PengHaixiangH | lld:pubmed |
| pubmed-article:12878703 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12878703 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:12878703 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12878703 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12878703 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12878703 | pubmed:pagination | 6617-26 | lld:pubmed |
| pubmed-article:12878703 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:meshHeading | pubmed-meshheading:12878703... | lld:pubmed |
| pubmed-article:12878703 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12878703 | pubmed:articleTitle | Identification of upregulated SCG10 mRNA expression associated with late-phase long-term potentiation in the rat hippocampal Schaffer-CA1 pathway in vivo. | lld:pubmed |
| pubmed-article:12878703 | pubmed:affiliation | Cajal Neuroscience Institute, Department of Biology, University of Texas, San Antonio, Texas 78249-0662, USA. hpeng@lonestar.utsa.edu | lld:pubmed |
| pubmed-article:12878703 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12878703 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12878703 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:84510 | entrezgene:pubmed | pubmed-article:12878703 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12878703 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12878703 | lld:pubmed |
