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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 10
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pubmed:dateCreated |
2003-9-8
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pubmed:abstractText |
Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no satisfactory treatment. Using experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis, we demonstrate that the cannabinoid system is neuroprotective during EAE. Mice deficient in the cannabinoid receptor CB1 tolerate inflammatory and excitotoxic insults poorly and develop substantial neurodegeneration following immune attack in EAE. In addition, exogenous CB1 agonists can provide significant neuroprotection from the consequences of inflammatory CNS disease in an experimental allergic uveitis model. Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-(2-hydroxy-4-(1,1-dimethylheptyl)p...,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoxazines,
http://linkedlifedata.com/resource/pubmed/chemical/Cannabinoids,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanols,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/GSP1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Monomeric GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/N-acetylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cannabinoid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Win 55212-2
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8950
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pubmed:author |
pubmed-author:AhmedZubairZ,
pubmed-author:CroxfordJ LudovicJL,
pubmed-author:CuznerM LouiseML,
pubmed-author:GiovannoniGavinG,
pubmed-author:HankeyDeborah J RDJ,
pubmed-author:JacksonSamuel JSJ,
pubmed-author:KudaJJ,
pubmed-author:LedentCatherineC,
pubmed-author:PetzoldAxelA,
pubmed-author:PocockJennifer MJM,
pubmed-author:PryceGarethG,
pubmed-author:ThompsonAlan JAJ
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2191-202
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pubmed:dateRevised |
2011-11-3
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pubmed:meshHeading |
pubmed-meshheading:12876144-Animals,
pubmed-meshheading:12876144-Aspartic Acid,
pubmed-meshheading:12876144-Axons,
pubmed-meshheading:12876144-Benzoxazines,
pubmed-meshheading:12876144-Cannabinoids,
pubmed-meshheading:12876144-Cyclohexanols,
pubmed-meshheading:12876144-Dizocilpine Maleate,
pubmed-meshheading:12876144-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:12876144-Excitatory Amino Acid Agonists,
pubmed-meshheading:12876144-Gene Deletion,
pubmed-meshheading:12876144-Humans,
pubmed-meshheading:12876144-Mice,
pubmed-meshheading:12876144-Mice, Transgenic,
pubmed-meshheading:12876144-Monomeric GTP-Binding Proteins,
pubmed-meshheading:12876144-Morpholines,
pubmed-meshheading:12876144-Multiple Sclerosis,
pubmed-meshheading:12876144-N-Methylaspartate,
pubmed-meshheading:12876144-Naphthalenes,
pubmed-meshheading:12876144-Nerve Degeneration,
pubmed-meshheading:12876144-Nuclear Proteins,
pubmed-meshheading:12876144-Receptors, Cannabinoid,
pubmed-meshheading:12876144-Receptors, Drug,
pubmed-meshheading:12876144-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:12876144-Retina,
pubmed-meshheading:12876144-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:12876144-Spinal Cord,
pubmed-meshheading:12876144-Uveitis
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pubmed:year |
2003
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pubmed:articleTitle |
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.
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pubmed:affiliation |
Department of Neuroinflammation, Institute of Neurology, University College London, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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