| pubmed-article:12875973 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C0221908 | lld:lifeskim |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C0205039 | lld:lifeskim |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C0205266 | lld:lifeskim |
| pubmed-article:12875973 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:12875973 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12875973 | pubmed:dateCreated | 2003-7-23 | lld:pubmed |
| pubmed-article:12875973 | pubmed:abstractText | Transforming growth factor (TGF)-beta is a potent multifunctional cytokine that is an essential regulator of epithelial proliferation. Because TGF-beta is expressed almost entirely in a latent state in vivo, a major source of regulation of TGF-beta function is its activation. A subset of integrins, alphavbeta8 and alphavbeta6, which are expressed in the human airway, has recently been shown to activate latent TGF-beta in vitro, suggesting a regulatory role for integrins in TGF-beta function in vivo. Here we have developed a novel, biologically relevant experimental model of human airway epithelium using intact human bronchial tissue. We have used this model to determine the function of integrin-mediated activation of TGF-beta in the airway. In human bronchial fragments cultured in vitro, authentic epithelial-stromal interactions were maintained and integrin and TGF-beta expression profiles correlated with profiles found in normal lung. In addition, in this model, we found that either the integrin alphavbeta8 or TGF-beta could inhibit airway epithelial cell proliferation. Furthermore, we found that one mechanism of integrin-alphavbeta8-dependent inhibition of cell proliferation was through activation of TGF-beta because anti-beta8 antibody blocked the majority (76%) of active TGF-beta released from bronchial fragments. These data provide compelling evidence for a functional role for integrin-mediated activation of TGF-beta in control of human airway epithelial proliferation in vivo. | lld:pubmed |
| pubmed-article:12875973 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12875973 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12875973 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12875973 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12875973 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12875973 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:12875973 | pubmed:author | pubmed-author:CambierStepha... | lld:pubmed |
| pubmed-article:12875973 | pubmed:author | pubmed-author:Fjellbirkelan... | lld:pubmed |
| pubmed-article:12875973 | pubmed:author | pubmed-author:BroaddusV... | lld:pubmed |
| pubmed-article:12875973 | pubmed:author | pubmed-author:NishimuraStep... | lld:pubmed |
| pubmed-article:12875973 | pubmed:author | pubmed-author:JablonsDavidD | lld:pubmed |
| pubmed-article:12875973 | pubmed:author | pubmed-author:DolganovGrego... | lld:pubmed |
| pubmed-article:12875973 | pubmed:author | pubmed-author:HillArthurA | lld:pubmed |
| pubmed-article:12875973 | pubmed:author | pubmed-author:BrunettaPaulP | lld:pubmed |
| pubmed-article:12875973 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12875973 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:12875973 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12875973 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12875973 | pubmed:pagination | 533-42 | lld:pubmed |
| pubmed-article:12875973 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:meshHeading | pubmed-meshheading:12875973... | lld:pubmed |
| pubmed-article:12875973 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12875973 | pubmed:articleTitle | Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue. | lld:pubmed |
| pubmed-article:12875973 | pubmed:affiliation | Department of Anatomic Pathology and Lung Biology Center, San Francisco General Hospital, University of California at San Francisco/Mt. Zion Cancer Center, San Francisco, California 94110, USA. | lld:pubmed |
| pubmed-article:12875973 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12875973 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12875973 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12875973 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3685 | entrezgene:pubmed | pubmed-article:12875973 | lld:entrezgene |
| entrez-gene:7040 | entrezgene:pubmed | pubmed-article:12875973 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12875973 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12875973 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12875973 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12875973 | lld:pubmed |
