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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-7-22
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pubmed:abstractText |
Several drugs that primarily act on gamma-aminobutyrate or muscarinic receptors have been used to treat downbeat nystagmus (DBN) syndrome despite their having only moderate success and causing several side effects that limit their effectiveness. These drugs were tested under the assumption that DBN was caused by a disinhibition of a physiologic inhibitory cerebellar input on vestibular nuclei.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1526-632X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-70
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12874393-4-Aminopyridine,
pubmed-meshheading:12874393-Action Potentials,
pubmed-meshheading:12874393-Aged,
pubmed-meshheading:12874393-Aged, 80 and over,
pubmed-meshheading:12874393-Cerebellum,
pubmed-meshheading:12874393-Cross-Over Studies,
pubmed-meshheading:12874393-Double-Blind Method,
pubmed-meshheading:12874393-Female,
pubmed-meshheading:12874393-Humans,
pubmed-meshheading:12874393-Male,
pubmed-meshheading:12874393-Middle Aged,
pubmed-meshheading:12874393-Models, Neurological,
pubmed-meshheading:12874393-Nystagmus, Pathologic,
pubmed-meshheading:12874393-Potassium Channel Blockers,
pubmed-meshheading:12874393-Potassium Channels,
pubmed-meshheading:12874393-Prospective Studies,
pubmed-meshheading:12874393-Purkinje Cells,
pubmed-meshheading:12874393-Treatment Outcome,
pubmed-meshheading:12874393-Vestibular Nuclei
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pubmed:year |
2003
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pubmed:articleTitle |
Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study.
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pubmed:affiliation |
Department of Neurology, University of Munich, Germany. mstrupp@nefo.med.uni-muenchen.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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