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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-7-22
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pubmed:abstractText |
The roles of interleukin-4 (IL-4) and IL-13 in the regulation of immunity to Leishmania donovani infection are still poorly understood. Here we show that the increased parasite load observed in IL-4(-/-) and IL-4 receptor alpha(-/-) mice correlates with retarded granuloma maturation and antileishmanial activity and that the increased parasite load observed in IL-4 receptor alpha(-/-) mice correlates with increased NOS2 expression and decreased serum gamma interferon levels. IL-4 and IL-13 appear to play little role in regulating collagen deposition in L. donovani-induced granulomas.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-10229856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-10358179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-10491413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-11069076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-11120835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-11160238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-11160269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-11280075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-11703536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-11748180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-1901883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-3290381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-7591152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-8943737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-9104810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-9175832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-9379051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-9497481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-9780188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874364-9834100
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4804-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12874364-Animals,
pubmed-meshheading:12874364-Granuloma,
pubmed-meshheading:12874364-Interferon-gamma,
pubmed-meshheading:12874364-Interleukin-13,
pubmed-meshheading:12874364-Interleukin-4,
pubmed-meshheading:12874364-Leishmania donovani,
pubmed-meshheading:12874364-Leishmaniasis, Visceral,
pubmed-meshheading:12874364-Liver Diseases, Parasitic,
pubmed-meshheading:12874364-Mice,
pubmed-meshheading:12874364-Mice, Inbred BALB C,
pubmed-meshheading:12874364-Mice, Knockout,
pubmed-meshheading:12874364-Nitric Oxide Synthase,
pubmed-meshheading:12874364-Nitric Oxide Synthase Type II,
pubmed-meshheading:12874364-Receptors, Interleukin-4,
pubmed-meshheading:12874364-Signal Transduction
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pubmed:year |
2003
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pubmed:articleTitle |
Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity.
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pubmed:affiliation |
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
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pubmed:publicationType |
Journal Article
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