Linked Life Data

12874308

Source:http://linkedlifedata.com/resource/pubmed/id/12874308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2003-7-22
pubmed:abstractText
Immunoglobulin G (IgG) antibodies to three vaccine candidate preerythrocytic Plasmodium falciparum antigens were evaluated in children and adults in an epidemic-prone highland area of Kenya during rainy (high-transmission) and dry (low-transmission) seasons. The frequencies and median levels of IgG antibodies to circumsporozoite protein (CSP) and thrombospondin-related adhesive protein (TRAP) were compared to the frequencies and median levels of IgG antibodies to liver-stage antigen 1 (LSA-1) reported previously. The frequencies and median levels of IgG antibodies to CSP and TRAP were similar in children and adults in the rainy season, but they were lower in children than in adults in the dry season. The frequencies and median levels of antibodies to LSA-1 were lower in children than in adults in both the rainy and dry seasons. Antibodies to CSP and LSA-1 were primarily members of the IgG1 and IgG3 subclasses, while antibodies to TRAP were primarily members of the IgG3 and IgG4 subclasses. In a treatment-reinfection study following dry season testing, antibodies to TRAP were associated with a trend toward protection from infection in children (P = 0.051) but not in adults. Antibodies to LSA-1 and CSP did not correlate with protection in children or adults. In this highland area of Kenya with unstable transmission, IgG antibodies to preerythrocytic P. falciparum antigens vary in subjects by age and season, and the protective effects of these antibodies against infection may be different in adults and children.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-10354353, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-10382757, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-10948144, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-11132389, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-12135271, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-12164290, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-1440805, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-1548071, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-1951864, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-7515922, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-7538540, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-8055757, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-8335380, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-8988885, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-9186382, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-9234808, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-9393799, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-9607847, http://linkedlifedata.com/resource/pubmed/commentcorrection/12874308-9632590
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4320-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Antibodies to the Plasmodium falciparum antigens circumsporozoite protein, thrombospondin-related adhesive protein, and liver-stage antigen 1 vary by ages of subjects and by season in a highland area of Kenya.
pubmed:affiliation
Center for Global Health and Disease and Division of Pediatric Infectious Disease, Case Western Reserve University School of Medicine and Rainbow Babies and Children's Hospital, Cleveland, Ohio 44106, USA. ccj@cwru.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.