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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0007634,
umls-concept:C0039194,
umls-concept:C0042196,
umls-concept:C0085358,
umls-concept:C0205145,
umls-concept:C0220905,
umls-concept:C0439858,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1706438,
umls-concept:C2350466,
umls-concept:C2698600
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pubmed:issue |
3
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|
pubmed:dateCreated |
2003-7-22
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|
pubmed:abstractText |
Following inoculation of Ag into the anterior chamber (a.c.), systemic tolerance develops that is mediated in part by Ag-specific efferent CD8(+) T regulatory (Tr) cells. This model of tolerance is called a.c.-associated immune deviation. The generation of the efferent CD8(+) Tr cell in a.c.-associated immune deviation is dependent on IL-10-producing, CD1d-restricted, invariant Valpha14(+) NKT (iNKT) cells. The iNKT cell subpopulations are either CD4(+) or CD4(-)CD8(-) double negative. This report identifies the subpopulation of iNKT cells that is important for induction of the efferent Tr cell. Because MHC class II(-/-) (class II(-/-)) mice generate efferent Tr cells following a.c. inoculation, we conclude that conventional CD4(+) T cells are not needed for the development of efferent CD8(+) T cells. Furthermore, Ab depletion of CD4(+) cells in both wild-type mice (remove both conventional and CD4(+) NKT cells) and class II(-/-) mice (remove CD4(+) NKT cells) abrogated the generation of Tr cells. We conclude that CD4(+) NKT cells, but not the class II molecule or conventional CD4(+) T cells, are required for generation of efferent CD8(+) Tr cells following Ag introduction into the eye. Understanding the mechanisms that lead to the generation of efferent CD8(+) Tr cells may lead to novel immunotherapy for immune inflammatory diseases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1266-71
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12874214-Animals,
pubmed-meshheading:12874214-Anterior Chamber,
pubmed-meshheading:12874214-Antibodies, Monoclonal,
pubmed-meshheading:12874214-Antigens,
pubmed-meshheading:12874214-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12874214-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12874214-Cell Division,
pubmed-meshheading:12874214-Female,
pubmed-meshheading:12874214-Growth Inhibitors,
pubmed-meshheading:12874214-Histocompatibility Antigens Class II,
pubmed-meshheading:12874214-Injections,
pubmed-meshheading:12874214-Killer Cells, Natural,
pubmed-meshheading:12874214-Lymphocyte Activation,
pubmed-meshheading:12874214-Lymphocyte Count,
pubmed-meshheading:12874214-Lymphocyte Depletion,
pubmed-meshheading:12874214-Mice,
pubmed-meshheading:12874214-Mice, Inbred C57BL,
pubmed-meshheading:12874214-Mice, Knockout,
pubmed-meshheading:12874214-Ovalbumin,
pubmed-meshheading:12874214-Spleen,
pubmed-meshheading:12874214-T-Lymphocyte Subsets
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pubmed:year |
2003
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pubmed:articleTitle |
CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site.
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pubmed:affiliation |
Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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